PDBe 1jvp

X-ray diffraction
1.53Å resolution

Crystal structure of human CDK2 (unphosphorylated) in complex with PKF049-365

Released:
Source organism: Homo sapiens
Primary publication:
Structure-based design and protein X-ray analysis of a protein kinase inhibitor.
Bioorg. Med. Chem. Lett. 12 221-4 (2002)
PMID: 11755359

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 2 Chain: P
Molecule details ›
Chain: P
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM1A
Spacegroup: P212121
Unit cell:
a: 53.528Å b: 71.802Å c: 72.362Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.206 0.253
Expression system: Spodoptera frugiperda