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Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa

Source organism: Sus scrofa
Biochemical function: L-dopa decarboxylase activity
Biological process: serotonin biosynthetic process
Cellular component: cytoplasm

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EC 4.1.1.28: Aromatic-L-amino-acid decarboxylase

Reaction catalysed:
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO(2)
Systematic name:
Aromatic-L-amino-acid carboxy-lyase
Alternative Name(s):
  • 5-hydroxytryptophan decarboxylase
  • Aromatic amino acid decarboxylase
  • Aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)
  • DOPA decarboxylase
  • Hydroxytryptophan decarboxylase
  • L-DOPA decarboxylase
  • Tryptophan decarboxylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00282
Domain description: Pyridoxal-dependent decarboxylase conserved domain
Occurring in:
  1. Aromatic-L-amino-acid decarboxylase
The deposited structure of PDB entry 1js3 contains 2 copies of Pfam domain PF00282 (Pyridoxal-dependent decarboxylase conserved domain) in Aromatic-L-amino-acid decarboxylase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR010977
Domain description: Aromatic-L-amino-acid decarboxylase
Occurring in:
  1. Aromatic-L-amino-acid decarboxylase
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Aromatic-L-amino-acid decarboxylase
IPR021115
Domain description: Pyridoxal-phosphate binding site
Occurring in:
  1. Aromatic-L-amino-acid decarboxylase
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Aromatic-L-amino-acid decarboxylase
IPR002129
Domain description: Pyridoxal phosphate-dependent decarboxylase
Occurring in:
  1. Aromatic-L-amino-acid decarboxylase
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Aromatic-L-amino-acid decarboxylase

Structure domains

CATH CATH domains
3.90.1150.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aspartate Aminotransferase, domain 1
Homology: Aspartate Aminotransferase, domain 1
Occurring in:
  1. Aromatic-L-amino-acid decarboxylase
The deposited structure of PDB entry 1js3 contains 2 copies of CATH domain 3.90.1150.10 (Aspartate Aminotransferase, domain 1) in Aromatic-L-amino-acid decarboxylase. Showing 1 copy in chain A.
3.40.640.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aspartate Aminotransferase; domain 2
Homology: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Occurring in:
  1. Aromatic-L-amino-acid decarboxylase
The deposited structure of PDB entry 1js3 contains 2 copies of CATH domain 3.40.640.10 (Aspartate Aminotransferase; domain 2) in Aromatic-L-amino-acid decarboxylase. Showing 1 copy in chain A.
1.20.1340.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: dopa decarboxylase, N-terminal domain
Homology: dopa decarboxylase, N-terminal domain
Occurring in:
  1. Aromatic-L-amino-acid decarboxylase
The deposited structure of PDB entry 1js3 contains 2 copies of CATH domain 1.20.1340.10 (dopa decarboxylase, N-terminal domain) in Aromatic-L-amino-acid decarboxylase. Showing 1 copy in chain A.
SCOP SCOP annotation
69565
Class: Alpha and beta proteins (a/b)
Fold: PLP-dependent transferase-like
Superfamily: PLP-dependent transferases
Occurring in:
  1. Aromatic-L-amino-acid decarboxylase
The deposited structure of PDB entry 1js3 contains 2 copies of SCOP domain 69565 (Pyridoxal-dependent decarboxylase) in Aromatic-L-amino-acid decarboxylase. Showing 1 copy in chain A.

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