PDBe 1jpw

X-ray diffraction
2.5Å resolution

Crystal Structure of a Human Tcf-4 / beta-Catenin Complex

Released:
Source organism: Homo sapiens
Primary publication:
Structure of a human Tcf4-beta-catenin complex.
Nat. Struct. Biol. 8 1053-7 (2001)
PMID: 11713476

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Catenin beta-1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 540 amino acids
Theoretical weight: 58.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P35222 (Residues: 131-670; Coverage: 69%)
  • Best match: P35222-2 (Residues: 1-76, 77-86)
Gene names: CTNNB, CTNNB1, OK/SW-cl.35, PRO2286
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant
Transcription factor 7-like 2 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 49 amino acids
Theoretical weight: 5.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NQB0 (Residues: 6-54; Coverage: 8%)
Gene names: TCF4, TCF7L2

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: C2
Unit cell:
a: 376.53Å b: 92.65Å c: 49.25Å
α: 90° β: 95.98° γ: 90°
R-values:
R R work R free
0.304 0.304 0.39
Expression system: Escherichia coli BL21(DE3)