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The Structure of a beta-Catenin Binding Repeat from Adenomatous Polyposis Coli (APC) in Complex with beta-Catenin

X-ray diffraction
3.1Å resolution
PDB entry 1jpp coloured by chain, front view.
PDB entry 1jpp coloured by chain, side view.
PDB entry 1jpp coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Adenomatous polyposis coli protein and Catenin beta-1
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Multimeric state: hetero dimer
Accessible surface area: 24198.08 Å2
Buried surface area: 1096.99 Å2
Dissociation area: 548.5 Å2
Dissociation energy (ΔGdiss): -1.51 kcal/mol
Dissociation entropy (TΔSdiss): 7.74 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150350
Assembly 2 (preferred)
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Assembly Name: Adenomatous polyposis coli protein and Catenin beta-1
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Multimeric state: hetero dimer
Accessible surface area: 24418.68 Å2
Buried surface area: 1461.25 Å2
Dissociation area: 626.86 Å2
Dissociation energy (ΔGdiss): -1.44 kcal/mol
Dissociation entropy (TΔSdiss): 8.23 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150350

Macromolecules

Catenin beta-1
Chains: A, B
Length: 538 amino acids
Theoretical weight: 58.84 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q02248 (Residues: 134-671; Coverage: 69%)
Gene names: Catnb, Ctnnb1
Pfam: Armadillo/beta-catenin-like repeat
InterPro:
CATH: Leucine-rich Repeat Variant
SCOP: Armadillo repeat
Catenin beta-1 in PDB entry 1jpp, assembly 2, front view.
Catenin beta-1 in PDB entry 1jpp, assembly 2, side view.
Catenin beta-1 in PDB entry 1jpp, assembly 2, top view.
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Adenomatous polyposis coli protein
Chains: C, D
Length: 15 amino acids
Theoretical weight: 1.79 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P25054 (Residues: 1021-1035; Coverage: 1%)
Gene names: APC, DP2.5
Pfam: APC 15 residue motif
InterPro: Adenomatous polyposis coli protein, 15 residue repeat
Adenomatous polyposis coli protein in PDB entry 1jpp, assembly 2, front view.
Adenomatous polyposis coli protein in PDB entry 1jpp, assembly 2, side view.
Adenomatous polyposis coli protein in PDB entry 1jpp, assembly 2, top view.
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