PDBe 1jk8

X-ray diffraction
2.4Å resolution

Crystal structure of a human insulin peptide-HLA-DQ8 complex

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Insulin B chain Chain: C
Molecule details ›
Chain: C
Length: 14 amino acids
Theoretical weight: 1.48 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Best match: P01308 (Residues: 35-47)
Gene name: INS
HLA class II histocompatibility antigen, DQ alpha 1 chain Chain: A
Molecule details ›
Chain: A
Length: 181 amino acids
Theoretical weight: 20.73 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Best match: P01909 (Residues: 27-78, 79-206)
Gene name: HLA-DQA1
HLA class II histocompatibility antigen, DQ beta 1 chain Chain: B
Molecule details ›
Chain: B
Length: 190 amino acids
Theoretical weight: 22.33 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Best match: P01920 (Residues: 35-224)
Gene names: HLA-DQB, HLA-DQB1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P21
Unit cell:
a: 66.034Å b: 42.862Å c: 87.467Å
α: 90° β: 102.48° γ: 90°
R-values:
R R work R free
0.224 0.224 0.258
Expression systems:
  • Not provided
  • Spodoptera frugiperda