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CRYSTAL STRUCTURE AND MECHANISM OF L-ARGININE: GLYCINE AMIDINOTRANSFERASE: A MITOCHONDRIAL ENZYME INVOLVED IN CREATINE BIOSYNTHESIS

Source organism: Homo sapiens
Biochemical function: transferase activity
Biological process: positive regulation of cold-induced thermogenesis
Cellular component: extracellular exosome

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EC 2.1.4.1: Glycine amidinotransferase

Reaction catalysed:
L-arginine + glycine = L-ornithine + guanidinoacetate
Systematic name:
L-arginine:glycine amidinotransferase
Alternative Name(s):
  • Arginine-glycine amidinotransferase
  • Arginine-glycine transamidinase
  • Glycine transamidinase

GO terms

Sequence family

InterPro InterPro annotation
IPR033195
Domain description: Glycine/inosamine-phosphate amidinotransferase
Occurring in:
  1. Glycine amidinotransferase, mitochondrial

Structure domain

CATH CATH domain
3.75.10.10
Class: Alpha Beta
Architecture: 5-stranded Propeller
Topology: L-arginine/glycine Amidinotransferase; Chain A
Homology: L-arginine/glycine Amidinotransferase; Chain A
Occurring in:
  1. Glycine amidinotransferase, mitochondrial
The deposited structure of PDB entry 1jdw contains 1 copy of CATH domain 3.75.10.10 (L-arginine/glycine Amidinotransferase; Chain A) in Glycine amidinotransferase, mitochondrial. Showing 1 copy in chain A.
SCOP SCOP annotation
55914
Class: Alpha and beta proteins (a+b)
Fold: Pentein, beta/alpha-propeller
Superfamily: Pentein
Occurring in:
  1. Glycine amidinotransferase, mitochondrial
The deposited structure of PDB entry 1jdw contains 1 copy of SCOP domain 55914 (Amidinotransferase) in Glycine amidinotransferase, mitochondrial. Showing 1 copy in chain A.

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