PDBe 1jdh

X-ray diffraction
1.9Å resolution

CRYSTAL STRUCTURE OF BETA-CATENIN AND HTCF-4

Released:
Source organism: Homo sapiens
Primary publication:
Tcf4 can specifically recognize beta-catenin using alternative conformations.
Nat. Struct. Biol. 8 1048-52 (2001)
PMID: 11713475

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transcription factor 7-like 2 Chain: B
Molecule details ›
Chain: B
Length: 38 amino acids
Theoretical weight: 4.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NQB0 (Residues: 12-49; Coverage: 6%)
Gene names: TCF4, TCF7L2
Catenin beta-1 Chain: A
Molecule details ›
Chain: A
Length: 529 amino acids
Theoretical weight: 57.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35222 (Residues: 135-663; Coverage: 68%)
Gene names: CTNNB, CTNNB1, OK/SW-cl.35, PRO2286
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE
Spacegroup: P212121
Unit cell:
a: 49.77Å b: 76.033Å c: 159.129Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.203 0.231
Expression system: Escherichia coli