PDBe 1jcn

X-ray diffraction
2.5Å resolution

BINARY COMPLEX OF HUMAN TYPE-I INOSINE MONOPHOSPHATE DEHYDROGENASE WITH 6-CL-IMP

Released:
Source organism: Homo sapiens
Entry authors: Risal D, Strickler MD, Goldstein BM

Function and Biology Details

Reaction catalysed:
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
homo tetramer (preferred)
homo octamer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inosine-5'-monophosphate dehydrogenase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 514 amino acids
Theoretical weight: 55.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P20839 (Residues: 1-514; Coverage: 100%)
Gene names: IMPD1, IMPDH1
Sequence domains:
Structure domains: Aldolase class I

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: I4
Unit cell:
a: 148.108Å b: 148.108Å c: 122.016Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.238 0.271
Expression system: Escherichia coli BL21(DE3)