Function and Biology

Crystal Structure of Native Methylmalonyl-CoA Epimerase

Source organism: Propionibacterium freudenreichii subsp. shermanii
Biochemical function: isomerase activity
Biological process: not assigned
Cellular component: not assigned

EC 5.1.99.1: Methylmalonyl-CoA epimerase

Reaction catalysed:
(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA.
Systematic name:
Methylmalonyl-CoA 2-epimerase
Alternative Name(s):
  • 2-methyl-3-oxopropanoyl-CoA 2-epimerase
  • DL-methylmalonyl-CoA racemase
  • Methylmalonyl coenzyme A racemase
  • Methylmalonyl-CoA racemase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF13669
Domain description: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
Occurring in:
  1. Methylmalonyl-CoA epimerase
1 copy of Pfam domain PF13669 (Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily) in Methylmalonyl-CoA epimerase in PDB 1jc5.

InterPro InterPro annotations
IPR029068
Domain description: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
Occurring in:
  1. Methylmalonyl-CoA epimerase
IPR017515
Domain description: Methylmalonyl-CoA epimerase
Occurring in:
  1. Methylmalonyl-CoA epimerase
IPR037523
Domain description: Vicinal oxygen chelate (VOC) domain
Occurring in:
  1. Methylmalonyl-CoA epimerase

Structure domain

CATH CATH domain
3.10.180.10
Class: Alpha Beta
Architecture: Roll
Topology: 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1
Homology: 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1
Occurring in:
  1. Methylmalonyl-CoA epimerase
1 copy of CATH domain 3.10.180.10 (2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1) in Methylmalonyl-CoA epimerase in PDB 1jc5.
SCOP SCOP annotation
64257
Class: Alpha and beta proteins (a+b)
Fold: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
Superfamily: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
Occurring in:
  1. Methylmalonyl-CoA epimerase
1 copy of SCOP domain 64257 (Methylmalonyl-CoA epimerase) in Methylmalonyl-CoA epimerase in PDB 1jc5.