PDBe 1j37

X-ray diffraction
2.4Å resolution

Crystal Structure of Drosophila AnCE

Released:

Function and Biology Details

Reaction catalysed:
Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II. 
Biochemical function:
Biological process:
Cellular component:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiotensin-converting enzyme Chains: A, B
Molecule details ›
Chains: A, B
Length: 607 amino acids
Theoretical weight: 70.44 KDa
Source organism: Drosophila melanogaster
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q10714 (Residues: 14-615; Coverage: 100%)
Gene names: Ance, CG8827, Race
Sequence domains: Angiotensin-converting enzyme

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P21
Unit cell:
a: 94.912Å b: 121.223Å c: 94.74Å
α: 90° β: 99.39° γ: 90°
R-values:
R R work R free
0.241 0.241 0.283
Expression system: Spodoptera frugiperda