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ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN

X-ray diffraction
2Å resolution
PDB entry 1izb coloured by chain, front view.
PDB entry 1izb coloured by chain, side view.
PDB entry 1izb coloured by chain, top view.
Source organism: Sus scrofa
Assemblies composition:
hetero dimer (preferred)
hetero dodecamer
hetero hexamer
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Insulin B chain
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Multimeric state: hetero dimer
Accessible surface area: 3656.55 Å2
Buried surface area: 1771.92 Å2
Dissociation area: 850.14 Å2
Dissociation energy (ΔGdiss): 11.18 kcal/mol
Dissociation entropy (TΔSdiss): 8.21 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134237
Assembly 2
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Assembly Name: Insulin B chain
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Multimeric state: hetero dimer
Accessible surface area: 3525.16 Å2
Buried surface area: 1901.54 Å2
Dissociation area: 917.1 Å2
Dissociation energy (ΔGdiss): 12.14 kcal/mol
Dissociation entropy (TΔSdiss): 8.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134237
Assembly 3
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Assembly Name: Insulin B chain
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Multimeric state: hetero dodecamer
Accessible surface area: 12137.89 Å2
Buried surface area: 20032.92 Å2
Dissociation area: 4,494.28 Å2
Dissociation energy (ΔGdiss): 65.37 kcal/mol
Dissociation entropy (TΔSdiss): 12.88 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-134248
Assembly 4
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Assembly Name: Insulin B chain
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Multimeric state: hetero dodecamer
Accessible surface area: 18375.96 Å2
Buried surface area: 13794.84 Å2
Dissociation area: 1,196.48 Å2
Dissociation energy (ΔGdiss): 0.8 kcal/mol
Dissociation entropy (TΔSdiss): 11.97 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-134248
Assembly 5
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Assembly Name: Insulin B chain
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Multimeric state: hetero hexamer
Accessible surface area: 10578.73 Å2
Buried surface area: 5505.79 Å2
Dissociation area: 205.48 Å2
Dissociation energy (ΔGdiss): 20.18 kcal/mol
Dissociation entropy (TΔSdiss): 19.07 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134245
Assembly 6
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Assembly Name: Insulin B chain
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Multimeric state: hetero hexamer
Accessible surface area: 10180.48 Å2
Buried surface area: 5905.81 Å2
Dissociation area: 204.67 Å2
Dissociation energy (ΔGdiss): 21.54 kcal/mol
Dissociation entropy (TΔSdiss): 18.97 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134245
Assembly 7
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Assembly Name: Insulin B chain
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Multimeric state: hetero tetramer
Accessible surface area: 5669.99 Å2
Buried surface area: 5188.12 Å2
Dissociation area: 813.64 Å2
Dissociation energy (ΔGdiss): 5.3 kcal/mol
Dissociation entropy (TΔSdiss): 9.66 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-134242
Assembly 8
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Assembly Name: Insulin B chain
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Multimeric state: hetero tetramer
Accessible surface area: 5815.77 Å2
Buried surface area: 5039.41 Å2
Dissociation area: 686.05 Å2
Dissociation energy (ΔGdiss): 1.39 kcal/mol
Dissociation entropy (TΔSdiss): 9.65 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-134242

Macromolecules

Insulin A chain
Chains: A, C
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Sus scrofa
Expression system: Not provided
UniProt:
  • Canonical: P01315 (Residues: 88-108; Coverage: 25%)
Gene name: INS
InterPro:
SCOP: Insulin-like
Insulin A chain in PDB entry 1izb, assembly 1, front view.
Insulin A chain in PDB entry 1izb, assembly 1, side view.
Insulin A chain in PDB entry 1izb, assembly 1, top view.
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Insulin B chain
Chains: B, D
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Sus scrofa
Expression system: Not provided
UniProt:
  • Canonical: P01315 (Residues: 25-53; Coverage: 35%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
SCOP: Insulin-like
Insulin B chain in PDB entry 1izb, assembly 1, front view.
Insulin B chain in PDB entry 1izb, assembly 1, side view.
Insulin B chain in PDB entry 1izb, assembly 1, top view.
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