PDBe 1itq

X-ray diffraction
2.3Å resolution

HUMAN RENAL DIPEPTIDASE

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
Hydrolysis of dipeptides. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 369 amino acids
Theoretical weight: 41.11 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P16444 (Residues: 17-385; Coverage: 93%)
Gene names: DPEP1, MDP, RDP
Sequence domains: Membrane dipeptidase (Peptidase family M19)
Structure domains: Metal-dependent hydrolases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21
Unit cell:
a: 81.948Å b: 81.213Å c: 57.164Å
α: 90° β: 96.73° γ: 90°
R-values:
R R work R free
0.187 0.181 0.258
Expression system: Komagataella pastoris