PDBe 1itb

X-ray diffraction
2.5Å resolution

TYPE-1 INTERLEUKIN-1 RECEPTOR COMPLEXED WITH INTERLEUKIN-1 BETA

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-1 beta Chain: A
Molecule details ›
Chain: A
Length: 153 amino acids
Theoretical weight: 17.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01584 (Residues: 117-269; Coverage: 57%)
Gene names: IL1B, IL1F2
Sequence domains: Interleukin-1 / 18
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Interleukin-1 receptor type 1, soluble form Chain: B
Molecule details ›
Chain: B
Length: 315 amino acids
Theoretical weight: 36.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14778 (Residues: 18-332; Coverage: 57%)
Gene names: IL1R, IL1R1, IL1RA, IL1RT1
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: C2
Unit cell:
a: 146.952Å b: 68.452Å c: 65.867Å
α: 90° β: 108.95° γ: 90°
R-values:
R R work R free
0.229 0.229 0.325
Expression system: Escherichia coli