PDBe 1ir3

X-ray diffraction
1.9Å resolution

PHOSPHORYLATED INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH PEPTIDE SUBSTRATE AND ATP ANALOG

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin receptor subunit beta Chain: A
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 35.03 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Best match: P06213 (Residues: 1005-1310)
Gene name: INSR
PEPTIDE SUBSTRATE Chain: B
Molecule details ›
Chain: B
Length: 18 amino acids
Theoretical weight: 1.96 KDa
Source organism: Unidentified
Expression system: Not provided

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P3221
Unit cell:
a: 66.505Å b: 66.505Å c: 139.095Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.194 0.226
Expression systems:
  • Spodoptera frugiperda
  • Not provided