PDBe 1io6

Solution NMR

GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 (GRB2) C-TERMINAL SH3 DOMAIN COMPLEXED WITH A LIGAND PEPTIDE (NMR, MINIMIZED MEAN STRUCTURE)

Released:
Entry authors: Kawasaki M, Ogura K, Hatanaka H, Inagaki F

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
A LIGAND PEPTIDE Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.25 KDa
Source organism: Synthetic construct
Expression system: Not provided
Growth factor receptor-bound protein 2 Chain: A
Molecule details ›
Chain: A
Length: 59 amino acids
Theoretical weight: 6.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P62993 (Residues: 159-215; Coverage: 26%)
Gene names: ASH, GRB2
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Expression systems:
  • Not provided
  • Escherichia coli BL21(DE3)