PDBe 1inh

X-ray diffraction
2.4Å resolution

INFLUENZA A SUBTYPE N2 NEURAMINIDASE COMPLEXED WITH AROMATIC BANA111 INHIBITOR

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuraminidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 388 amino acids
Theoretical weight: 43.14 KDa
Source organism: Influenza A virus
UniProt:
  • Canonical: P06820 (Residues: 82-469; Coverage: 83%)
Gene name: NA
Structure domains: Neuraminidase

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2221
Unit cell:
a: 119.74Å b: 141.02Å c: 141.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.184 not available