Reviews - 1ilh mentioned but not cited (4)
- Role of CAR and PXR in xenobiotic sensing and metabolism. Wang YM, Ong SS, Chai SC, Chen T. Expert Opin Drug Metab Toxicol 8 803-817 (2012)
- How to do an evaluation: pitfalls and traps. Hawkins PC, Warren GL, Skillman AG, Nicholls A. J Comput Aided Mol Des 22 179-190 (2008)
- A current structural perspective on PXR and CAR in drug metabolism. Buchman CD, Chai SC, Chen T. Expert Opin Drug Metab Toxicol 14 635-647 (2018)
- Allosteric Antagonism of the Pregnane X Receptor (PXR): Current-State-of-the-Art and Prediction of Novel Allosteric Sites. Kamaraj R, Drastik M, Maixnerova J, Pavek P. Cells 11 2974 (2022)
Articles - 1ilh mentioned but not cited (13)
- A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity. Dussault I, Lin M, Hollister K, Fan M, Termini J, Sherman MA, Forman BM. Mol Cell Biol 22 5270-5280 (2002)
- Structure of the murine constitutive androstane receptor complexed to androstenol: a molecular basis for inverse agonism. Shan L, Vincent J, Brunzelle JS, Dussault I, Lin M, Ianculescu I, Sherman MA, Forman BM, Fernandez EJ. Mol Cell 16 907-917 (2004)
- The structural basis of pregnane X receptor binding promiscuity. Ngan CH, Beglov D, Rudnitskaya AN, Kozakov D, Waxman DJ, Vajda S. Biochemistry 48 11572-11581 (2009)
- Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway. Dou W, Zhang J, Li H, Kortagere S, Sun K, Ding L, Ren G, Wang Z, Mani S. J Nutr Biochem 25 923-933 (2014)
- Identifying unexpected therapeutic targets via chemical-protein interactome. Yang L, Chen J, Shi L, Hudock MP, Wang K, He L. PLoS One 5 e9568 (2010)
- Molecular basis for specificity in the druggable kinome: sequence-based analysis. Chen J, Zhang X, Fernández A. Bioinformatics 23 563-572 (2007)
- Activation of PXR by alantolactone ameliorates DSS-induced experimental colitis via suppressing NF-κB signaling pathway. Ren Y, Yue B, Ren G, Yu Z, Luo X, Sun A, Zhang J, Han M, Wang Z, Dou W. Sci Rep 9 16636 (2019)
- Exploring the PXR ligand binding mechanism with advanced Molecular Dynamics methods. Motta S, Callea L, Giani Tagliabue S, Bonati L. Sci Rep 8 16207 (2018)
- Monocrotophos induces the expression and activity of xenobiotic metabolizing enzymes in pre-sensitized cultured human brain cells. Tripathi VK, Kumar V, Singh AK, Kashyap MP, Jahan S, Pandey A, Alam S, Khan F, Khanna VK, Yadav S, Lohani M, Pant AB. PLoS One 9 e91946 (2014)
- Screening Ingredients from Herbs against Pregnane X Receptor in the Study of Inductive Herb-Drug Interactions: Combining Pharmacophore and Docking-Based Rank Aggregation. Cui Z, Kang H, Tang K, Liu Q, Cao Z, Zhu R. Biomed Res Int 2015 657159 (2015)
- Statins Increase Plasminogen Activator Inhibitor Type 1 Gene Transcription through a Pregnane X Receptor Regulated Element. Stanley FM, Linder KM, Cardozo TJ. PLoS One 10 e0138097 (2015)
- Identification of novel pregnane X receptor (PXR) agonists by In silico and biological activity analyses and reversal of cigarette smoke-induced PXR downregulation. Reddy RT, Nyunoya T. Biochem Biophys Res Commun 555 1-6 (2021)
- UV light-driven late-stage skeletal reorganization to diverse limonoid frameworks: A proof of concept for photobiosynthesis. Wu J, Li SJ, Jiang L, Ma XC, Lan Y, Shen L. Sci Adv 9 eade2981 (2023)
Reviews citing this publication (143)
- Clinical importance of the cytochromes P450. Nebert DW, Russell DW. Lancet 360 1155-1162 (2002)
- Multidrug resistance in bacteria. Nikaido H. Annu Rev Biochem 78 119-146 (2009)
- The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Kliewer SA, Goodwin B, Willson TM. Endocr Rev 23 687-702 (2002)
- Multiple molecular mechanisms for multidrug resistance transporters. Higgins CF. Nature 446 749-757 (2007)
- Implications of protein flexibility for drug discovery. Teague SJ. Nat Rev Drug Discov 2 527-541 (2003)
- PXR, CAR and drug metabolism. Willson TM, Kliewer SA. Nat Rev Drug Discov 1 259-266 (2002)
- Inhibition and induction of human cytochrome P450 enzymes: current status. Pelkonen O, Turpeinen M, Hakkola J, Honkakoski P, Hukkanen J, Raunio H. Arch Toxicol 82 667-715 (2008)
- Induction of drug metabolism: the role of nuclear receptors. Handschin C, Meyer UA. Pharmacol Rev 55 649-673 (2003)
- CAR and PXR: the xenobiotic-sensing receptors. Timsit YE, Negishi M. Steroids 72 231-246 (2007)
- Regulation of cyp3a gene transcription by the pregnane x receptor. Goodwin B, Redinbo MR, Kliewer SA. Annu Rev Pharmacol Toxicol 42 1-23 (2002)
- CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme. Wang H, Tompkins LM. Curr Drug Metab 9 598-610 (2008)
- Herbal modulation of P-glycoprotein. Zhou S, Lim LY, Chowbay B. Drug Metab Rev 36 57-104 (2004)
- Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR. Tolson AH, Wang H. Adv Drug Deliv Rev 62 1238-1249 (2010)
- ABC of oral bioavailability: transporters as gatekeepers in the gut. Dietrich CG, Geier A, Oude Elferink RP. Gut 52 1788-1795 (2003)
- Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration. Geier A, Wagner M, Dietrich CG, Trauner M. Biochim Biophys Acta 1773 283-308 (2007)
- Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects. di Masi A, De Marinis E, Ascenzi P, Marino M. Mol Aspects Med 30 297-343 (2009)
- Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes. Wang H, LeCluyse EL. Clin Pharmacokinet 42 1331-1357 (2003)
- Bile salts of vertebrates: structural variation and possible evolutionary significance. Hofmann AF, Hagey LR, Krasowski MD. J Lipid Res 51 226-246 (2010)
- Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism. Eloranta JJ, Kullak-Ublick GA. Arch Biochem Biophys 433 397-412 (2005)
- CYP induction-mediated drug interactions: in vitro assessment and clinical implications. Lin JH. Pharm Res 23 1089-1116 (2006)
- CAR and PXR: xenosensors of endocrine disrupters? Kretschmer XC, Baldwin WS. Chem Biol Interact 155 111-128 (2005)
- Mechanisms of cytochrome P450 induction. Tompkins LM, Wallace AD. J Biochem Mol Toxicol 21 176-181 (2007)
- Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters. Chen Y, Tang Y, Guo C, Wang J, Boral D, Nie D. Biochem Pharmacol 83 1112-1126 (2012)
- Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man. Gibson GG, Plant NJ, Swales KE, Ayrton A, El-Sankary W. Xenobiotica 32 165-206 (2002)
- Structure and function of efflux pumps that confer resistance to drugs. Borges-Walmsley MI, McKeegan KS, Walmsley AR. Biochem J 376 313-338 (2003)
- Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor. Chen J, Raymond K. Ann Clin Microbiol Antimicrob 5 3 (2006)
- Liver hypertrophy: a review of adaptive (adverse and non-adverse) changes--conclusions from the 3rd International ESTP Expert Workshop. Hall AP, Elcombe CR, Foster JR, Harada T, Kaufmann W, Knippel A, Küttler K, Malarkey DE, Maronpot RR, Nishikawa A, Nolte T, Schulte A, Strauss V, York MJ. Toxicol Pathol 40 971-994 (2012)
- Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux. Loo TW, Clarke DM. J Membr Biol 206 173-185 (2005)
- Neurosteroid regulation of central nervous system development. Mellon SH. Pharmacol Ther 116 107-124 (2007)
- Nuclear receptors and nonalcoholic fatty liver disease. Cave MC, Clair HB, Hardesty JE, Falkner KC, Feng W, Clark BJ, Sidey J, Shi H, Aqel BA, McClain CJ, Prough RA. Biochim Biophys Acta 1859 1083-1099 (2016)
- Nuclear receptors and drug disposition gene regulation. Tirona RG, Kim RB. J Pharm Sci 94 1169-1186 (2005)
- Drug-activated nuclear receptors CAR and PXR. Honkakoski P, Sueyoshi T, Negishi M. Ann Med 35 172-182 (2003)
- International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor. Moore DD, Kato S, Xie W, Mangelsdorf DJ, Schmidt DR, Xiao R, Kliewer SA. Pharmacol Rev 58 742-759 (2006)
- The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. Zhou C, Verma S, Blumberg B. Nucl Recept Signal 7 e001 (2009)
- Activation of nuclear receptors: a perspective from structural genomics. Li Y, Lambert MH, Xu HE. Structure 11 741-746 (2003)
- Nuclear hormone receptor co-repressors: structure and function. Watson PJ, Fairall L, Schwabe JW. Mol Cell Endocrinol 348 440-449 (2012)
- Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Handschin C, Meyer UA. Arch Biochem Biophys 433 387-396 (2005)
- Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond. Chai X, Zeng S, Xie W. Expert Opin Drug Metab Toxicol 9 253-266 (2013)
- Waltzing transporters and 'the dance macabre' between humans and bacteria. Lomovskaya O, Zgurskaya HI, Totrov M, Watkins WJ. Nat Rev Drug Discov 6 56-65 (2007)
- Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds. Reschly EJ, Krasowski MD. Curr Drug Metab 7 349-365 (2006)
- PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity. Stanley LA, Horsburgh BC, Ross J, Scheer N, Wolf CR. Drug Metab Rev 38 515-597 (2006)
- P-glycoprotein: so many ways to turn it on. Callaghan R, Crowley E, Potter S, Kerr ID. J Clin Pharmacol 48 365-378 (2008)
- Cytochrome P450 3A and their regulation. Burk O, Wojnowski L. Naunyn Schmiedebergs Arch Pharmacol 369 105-124 (2004)
- Endogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C disease. Mellon SH, Gong W, Schonemann MD. Brain Res Rev 57 410-420 (2008)
- Predicting undesirable drug interactions with promiscuous proteins in silico. Ekins S. Drug Discov Today 9 276-285 (2004)
- Retinoic acid actions through mammalian nuclear receptors. Huang P, Chandra V, Rastinejad F. Chem Rev 114 233-254 (2014)
- Structural mechanisms of multidrug recognition and regulation by bacterial multidrug transcription factors. Schumacher MA, Brennan RG. Mol Microbiol 45 885-893 (2002)
- FXR and PXR: potential therapeutic targets in cholestasis. Jonker JW, Liddle C, Downes M. J Steroid Biochem Mol Biol 130 147-158 (2012)
- Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions. Pavek P. Front Pharmacol 7 456 (2016)
- Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism. Xie W, Uppal H, Saini SP, Mu Y, Little JM, Radominska-Pandya A, Zemaitis MA. Drug Discov Today 9 442-449 (2004)
- Role of CYP pharmacogenetics and drug-drug interactions in the efficacy and safety of atypical and other antipsychotic agents. Murray M. J Pharm Pharmacol 58 871-885 (2006)
- Targeting xenobiotic receptors PXR and CAR in human diseases. Banerjee M, Robbins D, Chen T. Drug Discov Today 20 618-628 (2015)
- Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical. Sinz M, Wallace G, Sahi J. AAPS J 10 391-400 (2008)
- Mystery of multidrug transporters: the answer can be simple. Neyfakh AA. Mol Microbiol 44 1123-1130 (2002)
- Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily. Smutny T, Mani S, Pavek P. Curr Drug Metab 14 1059-1069 (2013)
- PXR: More Than Just a Master Xenobiotic Receptor. Oladimeji PO, Chen T. Mol Pharmacol 93 119-127 (2018)
- Molecular basis of the selective activity of vitamin D analogues. Carlberg C. J Cell Biochem 88 274-281 (2003)
- A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta. Ekins S, Mirny L, Schuetz EG. Pharm Res 19 1788-1800 (2002)
- Vitamin E and drug metabolism. Brigelius-Flohé R. Biochem Biophys Res Commun 305 737-740 (2003)
- PXR antagonists and implication in drug metabolism. Mani S, Dou W, Redinbo MR. Drug Metab Rev 45 60-72 (2013)
- Progress in computational toxicology. Ekins S. J Pharmacol Toxicol Methods 69 115-140 (2014)
- Overcoming drug resistance by regulating nuclear receptors. Chen T. Adv Drug Deliv Rev 62 1257-1264 (2010)
- Mechanisms of xenobiotic receptor activation: Direct vs. indirect. Mackowiak B, Wang H. Biochim Biophys Acta 1859 1130-1140 (2016)
- The structure and function of drug pumps: an update. McKeegan KS, Borges-Walmsley MI, Walmsley AR. Trends Microbiol 11 21-29 (2003)
- Orphan nuclear receptors adopted by crystallography. Ingraham HA, Redinbo MR. Curr Opin Struct Biol 15 708-715 (2005)
- A structural view of nuclear hormone receptor: endocrine disruptor interactions. le Maire A, Bourguet W, Balaguer P. Cell Mol Life Sci 67 1219-1237 (2010)
- Digging deep into the pockets of orphan nuclear receptors: insights from structural studies. Benoit G, Malewicz M, Perlmann T. Trends Cell Biol 14 369-376 (2004)
- Regulation of the cytosolic sulfotransferases by nuclear receptors. Runge-Morris M, Kocarek TA, Falany CN. Drug Metab Rev 45 15-33 (2013)
- Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists. Biswas A, Mani S, Redinbo MR, Krasowski MD, Li H, Ekins S. Pharm Res 26 1807-1815 (2009)
- The Roles of Xenobiotic Receptors: Beyond Chemical Disposition. Mackowiak B, Hodge J, Stern S, Wang H. Drug Metab Dispos 46 1361-1371 (2018)
- In silico tools to aid risk assessment of endocrine disrupting chemicals. Jacobs MN. Toxicology 205 43-53 (2004)
- Activation of xenobiotic receptors: driving into the nucleus. Li H, Wang H. Expert Opin Drug Metab Toxicol 6 409-426 (2010)
- Structural and functional insights into nuclear receptor signaling. Jin L, Li Y. Adv Drug Deliv Rev 62 1218-1226 (2010)
- Computational prediction of human drug metabolism. Ekins S, Andreyev S, Ryabov A, Kirillov E, Rakhmatulin EA, Bugrim A, Nikolskaya T. Expert Opin Drug Metab Toxicol 1 303-324 (2005)
- Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences. Pascussi JM, Gerbal-Chaloin S, Drocourt L, Assénat E, Larrey D, Pichard-Garcia L, Vilarem MJ, Maurel P. Xenobiotica 34 633-664 (2004)
- Small-molecule modulators of PXR and CAR. Chai SC, Cherian MT, Wang YM, Chen T. Biochim Biophys Acta 1859 1141-1154 (2016)
- Homology modelling of the nuclear receptors: human oestrogen receptorbeta (hERbeta), the human pregnane-X-receptor (PXR), the Ah receptor (AhR) and the constitutive androstane receptor (CAR) ligand binding domains from the human oestrogen receptor alpha (hERalpha) crystal structure, and the human peroxisome proliferator activated receptor alpha (PPARalpha) ligand binding domain from the human PPARgamma crystal structure. Jacobs MN, Dickins M, Lewis DF. J Steroid Biochem Mol Biol 84 117-132 (2003)
- Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective. Wallace BD, Redinbo MR. Drug Metab Rev 45 79-100 (2013)
- The identification of nuclear receptors associated with hepatic steatosis to develop and extend adverse outcome pathways. Mellor CL, Steinmetz FP, Cronin MT. Crit Rev Toxicol 46 138-152 (2016)
- Bioluminescent assays for ADMET. Cali JJ, Niles A, Valley MP, O'Brien MA, Riss TL, Shultz J. Expert Opin Drug Metab Toxicol 4 103-120 (2008)
- Genomic profiling in nuclear receptor-mediated toxicity. Woods CG, Heuvel JP, Rusyn I. Toxicol Pathol 35 474-494 (2007)
- A brief history of the discovery of PXR and CAR as xenobiotic receptors. Yan J, Xie W. Acta Pharm Sin B 6 450-452 (2016)
- Homologous metabolic and gene activating routes for vitamins E and K. Landes N, Birringer M, Brigelius-Flohé R. Mol Aspects Med 24 337-344 (2003)
- Pharmaceutical use of mouse models humanized for the xenobiotic receptor. Xie W, Evans RM. Drug Discov Today 7 509-515 (2002)
- Predictive ADMET studies, the challenges and the opportunities. Davis AM, Riley RJ. Curr Opin Chem Biol 8 378-386 (2004)
- Recent advances in P450 research. Raucy JL, Allen SW. Pharmacogenomics J 1 178-186 (2001)
- ABC Transporters: Regulation and Association with Multidrug Resistance in Hepatocellular Carcinoma and Colorectal Carcinoma. Ceballos MP, Rigalli JP, Ceré LI, Semeniuk M, Catania VA, Ruiz ML. Curr Med Chem 26 1224-1250 (2019)
- Induction of drug metabolizing enzymes by vitamin E. Brigelius-Flohé R. J Plant Physiol 162 797-802 (2005)
- Functional evolution of the pregnane X receptor. Iyer M, Reschly EJ, Krasowski MD. Expert Opin Drug Metab Toxicol 2 381-397 (2006)
- Phytochemical regulation of UDP-glucuronosyltransferases: implications for cancer prevention. Saracino MR, Lampe JW. Nutr Cancer 59 121-141 (2007)
- Pregnane X receptor and drug-induced liver injury. Wang YM, Chai SC, Brewer CT, Chen T. Expert Opin Drug Metab Toxicol 10 1521-1532 (2014)
- Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design. Togashi M, Borngraeber S, Sandler B, Fletterick RJ, Webb P, Baxter JD. J Steroid Biochem Mol Biol 93 127-137 (2005)
- Orphan nuclear receptors as targets for drug development. Mukherjee S, Mani S. Pharm Res 27 1439-1468 (2010)
- Pregnane X receptor- and CYP3A4-humanized mouse models and their applications. Cheng J, Ma X, Gonzalez FJ. Br J Pharmacol 163 461-468 (2011)
- Production of protein complexes via co-expression. Kerrigan JJ, Xie Q, Ames RS, Lu Q. Protein Expr Purif 75 1-14 (2011)
- Utility of protein structures in overcoming ADMET-related issues of drug-like compounds. Stoll F, Göller AH, Hillisch A. Drug Discov Today 16 530-538 (2011)
- Is there a future for antioxidants in atherogenesis? Brigelius-Flohé R, Kluth D, Banning A. Mol Nutr Food Res 49 1083-1089 (2005)
- A family-based approach reveals the function of residues in the nuclear receptor ligand-binding domain. Folkertsma S, van Noort P, Van Durme J, Joosten HJ, Bettler E, Fleuren W, Oliveira L, Horn F, de Vlieg J, Vriend G. J Mol Biol 341 321-335 (2004)
- Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development. Sinz MW. Drug Metab Rev 45 3-14 (2013)
- Evolution of thyroid hormone signaling in animals: Non-genomic and genomic modes of action. Taylor E, Heyland A. Mol Cell Endocrinol 459 14-20 (2017)
- P-glycoprotein (ABCB1) and Oxidative Stress: Focus on Alzheimer's Disease. Sita G, Hrelia P, Tarozzi A, Morroni F. Oxid Med Cell Longev 2017 7905486 (2017)
- Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability. Mbatchi LC, Brouillet JP, Evrard A. Pharmacogenomics 19 61-77 (2018)
- Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer. Chai SC, Wright WC, Chen T. Med Res Rev 40 1061-1083 (2020)
- Structural considerations of vitamin D signaling. Molnár F. Front Physiol 5 191 (2014)
- 3D structures and ligand specificities of nuclear xenobiotic receptors CAR, PXR and VDR. Wu B, Li S, Dong D. Drug Discov Today 18 574-581 (2013)
- Differential Regulation of CYP3A4 and CYP3A5 and its Implication in Drug Discovery. Lolodi O, Wang YM, Wright WC, Chen T. Curr Drug Metab 18 1095-1105 (2017)
- Transcriptional regulation of the human pregnane-X receptor. Gibson GG, Phillips A, Aouabdi S, Plant K, Plant N. Drug Metab Rev 38 31-49 (2006)
- Understanding nuclear receptors using computational methods. Ai N, Krasowski MD, Welsh WJ, Ekins S. Drug Discov Today 14 486-494 (2009)
- Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases. Garcia M, Thirouard L, Sedès L, Monrose M, Holota H, Caira F, Volle DH, Beaudoin C. Int J Mol Sci 19 E3630 (2018)
- Nuclear hormone receptor-dependent regulation of hepatic transporters and their role in the adaptive response in cholestasis. Stahl S, Davies MR, Cook DI, Graham MJ. Xenobiotica 38 725-777 (2008)
- The xenobiotic receptors PXR and CAR in liver physiology, an update. Cai X, Young GM, Xie W. Biochim Biophys Acta Mol Basis Dis 1867 166101 (2021)
- MD recognition by MDR gene regulators. Wade H. Curr Opin Struct Biol 20 489-496 (2010)
- Nuclear Receptors as Multiple Regulators of NLRP3 Inflammasome Function. Alatshan A, Benkő S. Front Immunol 12 630569 (2021)
- Cell-based systems to assess nuclear receptor activation and their use in drug development. Raucy JL, Lasker JM. Drug Metab Rev 45 101-109 (2013)
- Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor. Chai SC, Lin W, Li Y, Chen T. Drug Discov Today 24 906-915 (2019)
- Towards a new age of virtual ADME/TOX and multidimensional drug discovery. Ekins S, Boulanger B, Swaan PW, Hupcey MA. Mol Divers 5 255-275 (2002)
- Botanical compounds and their regulation of nuclear receptor action: the case of traditional Chinese medicine. Li L, Bonneton F, Chen XY, Laudet V. Mol Cell Endocrinol 401 221-237 (2015)
- Modulation of xenobiotic receptors by steroids. Banerjee M, Robbins D, Chen T. Molecules 18 7389-7406 (2013)
- Nuclear receptors: the evolution of diversity. Schwabe JW, Teichmann SA. Sci STKE 2004 pe4 (2004)
- Targeting the pregnane X receptor in liver injury. Li T, Yu RT, Atkins AR, Downes M, Tukey RH, Evans RM. Expert Opin Ther Targets 16 1075-1083 (2012)
- Biology of PXR: role in drug-hormone interactions. Wang J, Dai S, Guo Y, Xie W, Zhai Y. EXCLI J 13 728-739 (2014)
- Pregnane X receptor polymorphisms associated with human diseases. Kotta-Loizou I, Patsouris E, Theocharis S. Expert Opin Ther Targets 17 1167-1177 (2013)
- Usefulness of studies on the molecular mechanism of action of herbals/botanicals: The case of St. John's wort. Choudhuri S, Valerio LG. J Biochem Mol Toxicol 19 1-11 (2005)
- Long-term virus-induced alterations of CYP3A-mediated drug metabolism: a look at the virology, immunology and molecular biology of a multi-faceted problem. Croyle MA. Expert Opin Drug Metab Toxicol 5 1189-1211 (2009)
- Multiple Molecular Mechanisms to Overcome Multidrug Resistance in Cancer by Natural Secondary Metabolites. El-Readi MZ, Al-Abd AM, Althubiti MA, Almaimani RA, Al-Amoodi HS, Ashour ML, Wink M, Eid SY. Front Pharmacol 12 658513 (2021)
- PXR as a mediator of herb-drug interaction. Hogle BC, Guan X, Folan MM, Xie W. J Food Drug Anal 26 S26-S31 (2018)
- PXR cross-talks with internal and external signals in physiological and pathophysiological responses. Kodama S, Negishi M. Drug Metab Rev 45 300-310 (2013)
- Using TR-FRET to Investigate Protein-Protein Interactions: A Case Study of PXR-Coregulator Interaction. Lin W, Chen T. Adv Protein Chem Struct Biol 110 31-63 (2018)
- Beyond the human genome: examples of nuclear receptor analysis in model organisms and potential for drug discovery. Maglich JM, Sluder AE, Willson TM, Moore JT. Am J Pharmacogenomics 3 345-353 (2003)
- Insights into the critical role of the PXR in preventing carcinogenesis and chemotherapeutic drug resistance. Niu X, Wu T, Li G, Gu X, Tian Y, Cui H. Int J Biol Sci 18 742-759 (2022)
- Modulation of Nuclear Receptor Function by Chromatin Modifying Factor TIP60. Jaiswal B, Gupta A. Endocrinology 159 2199-2215 (2018)
- Alterations of chemotherapeutic pharmacokinetic profiles by drug-drug interactions. Mani S, Ghalib M, Chaudhary I, Goel S. Expert Opin Drug Metab Toxicol 5 109-130 (2009)
- Marine Ligands of the Pregnane X Receptor (PXR): An Overview. Carazo A, Mladěnka P, Pávek P. Mar Drugs 17 E554 (2019)
- PXR-mediated idiosyncratic drug-induced liver injury: mechanistic insights and targeting approaches. Wang J, Bwayi M, Gee RRF, Chen T. Expert Opin Drug Metab Toxicol 16 711-722 (2020)
- Predicting inductive drug-drug interactions. Liddle C, Robertson GR. Pharmacogenomics 4 141-152 (2003)
- Targeting nuclear receptors with marine natural products. Yang C, Li Q, Li Y. Mar Drugs 12 601-635 (2014)
- Pregnane X Receptor and P-glycoprotein: a connexion for Alzheimer's disease management. Jain S, Rathod V, Prajapati R, Nandekar PP, Sangamwar AT. Mol Divers 18 895-909 (2014)
- The Role of Vitamin K in Cholestatic Liver Disease. Sultana H, Komai M, Shirakawa H. Nutrients 13 2515 (2021)
- A concise review on hPXR ligand-recognizing residues and structure-based strategies to alleviate hPXR transactivation risk. Liu T, Beck JP, Hao J. RSC Med Chem 13 129-137 (2022)
- Mathematical Models in the Description of Pregnane X Receptor (PXR)-Regulated Cytochrome P450 Enzyme Induction. Tebbens JD, Azar M, Friedmann E, Lanzendörfer M, Pávek P. Int J Mol Sci 19 E1785 (2018)
- The role of pregnane X receptor (PXR) in substance metabolism. Lv Y, Luo YY, Ren HW, Li CJ, Xiang ZX, Luan ZL. Front Endocrinol (Lausanne) 13 959902 (2022)
- Arsenic: Various species with different effects on cytochrome P450 regulation in humans. El-Ghiaty MA, El-Kadi AOS. EXCLI J 20 1184-1242 (2021)
- Phenobarbital in Nuclear Receptor Activation: An Update. Men S, Wang H. Drug Metab Dispos 51 210-218 (2023)
Articles citing this publication (264)
- Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Science 323 1718-1722 (2009)
- Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4. Venkatesh M, Mukherjee S, Wang H, Li H, Sun K, Benechet AP, Qiu Z, Maher L, Redinbo MR, Phillips RS, Fleet JC, Kortagere S, Mukherjee P, Fasano A, Le Ven J, Nicholson JK, Dumas ME, Khanna KM, Mani S. Immunity 41 296-310 (2014)
- A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel JP, Nicolaou KC, Evans RM. Mol Cell 11 1079-1092 (2003)
- Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, Negishi M, Wang H. J Pharmacol Exp Ther 320 72-80 (2007)
- Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease. Hartz AM, Miller DS, Bauer B. Mol Pharmacol 77 715-723 (2010)
- Structure of a cation-bound multidrug and toxic compound extrusion transporter. He X, Szewczyk P, Karyakin A, Evin M, Hong WX, Zhang Q, Chang G. Nature 467 991-994 (2010)
- Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. Watkins RE, Davis-Searles PR, Lambert MH, Redinbo MR. J Mol Biol 331 815-828 (2003)
- All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta. Stehlin-Gaon C, Willmann D, Zeyer D, Sanglier S, Van Dorsselaer A, Renaud JP, Moras D, Schüle R. Nat Struct Biol 10 820-825 (2003)
- A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer. Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, Williams JD, Collins JL, Moore LB, Willson TM, Moore JT. Mol Cell 16 919-928 (2004)
- A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study. Yu EW, Aires JR, McDermott G, Nikaido H. J Bacteriol 187 6804-6815 (2005)
- Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome. Zhang Z, Burch PE, Cooney AJ, Lanz RB, Pereira FA, Wu J, Gibbs RA, Weinstock G, Wheeler DA. Genome Res 14 580-590 (2004)
- Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital. Hariparsad N, Nallani SC, Sane RS, Buckley DJ, Buckley AR, Desai PB. J Clin Pharmacol 44 1273-1281 (2004)
- The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization. Suino K, Peng L, Reynolds R, Li Y, Cha JY, Repa JJ, Kliewer SA, Xu HE. Mol Cell 16 893-905 (2004)
- Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1. Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA. Mol Cell 11 1575-1585 (2003)
- Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease. Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS. Proc Natl Acad Sci U S A 103 13807-13812 (2006)
- The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. Zhou C, Poulton EJ, Grün F, Bammler TK, Blumberg B, Thummel KE, Eaton DL. Mol Pharmacol 71 220-229 (2007)
- In vitro endocrine disruption potential of organophosphate flame retardants via human nuclear receptors. Kojima H, Takeuchi S, Itoh T, Iida M, Kobayashi S, Yoshida T. Toxicology 314 76-83 (2013)
- Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites. Ekins S, Chang C, Mani S, Krasowski MD, Reschly EJ, Iyer M, Kholodovych V, Ai N, Welsh WJ, Sinz M, Swaan PW, Patel R, Bachmann K. Mol Pharmacol 72 592-603 (2007)
- Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition. Bencharit S, Morton CL, Hyatt JL, Kuhn P, Danks MK, Potter PM, Redinbo MR. Chem Biol 10 341-349 (2003)
- The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily. Maglich JM, Caravella JA, Lambert MH, Willson TM, Moore JT, Ramamurthy L. Nucleic Acids Res 31 4051-4058 (2003)
- Alternatively spliced isoforms of the human constitutive androstane receptor. Auerbach SS, Ramsden R, Stoner MA, Verlinde C, Hassett C, Omiecinski CJ. Nucleic Acids Res 31 3194-3207 (2003)
- PPARs and lipid ligands in inflammation and metabolism. Harmon GS, Lam MT, Glass CK. Chem Rev 111 6321-6340 (2011)
- Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Jacobs MN, Nolan GT, Hood SR. Toxicol Appl Pharmacol 209 123-133 (2005)
- Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. Wang H, Venkatesh M, Li H, Goetz R, Mukherjee S, Biswas A, Zhu L, Kaubisch A, Wang L, Pullman J, Whitney K, Kuro-o M, Roig AI, Shay JW, Mohammadi M, Mani S. J Clin Invest 121 3220-3232 (2011)
- Structural plasticity in the oestrogen receptor ligand-binding domain. Nettles KW, Bruning JB, Gil G, O'Neill EE, Nowak J, Guo Y, Kim Y, DeSombre ER, Dilis R, Hanson RN, Joachimiak A, Greene GL. EMBO Rep 8 563-568 (2007)
- In vitro and in vivo induction of cytochrome p450: a survey of the current practices and recommendations: a pharmaceutical research and manufacturers of america perspective. Chu V, Einolf HJ, Evers R, Kumar G, Moore D, Ripp S, Silva J, Sinha V, Sinz M, Skerjanec A. Drug Metab Dispos 37 1339-1354 (2009)
- X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation. Stehlin C, Wurtz JM, Steinmetz A, Greiner E, Schüle R, Moras D, Renaud JP. EMBO J 20 5822-5831 (2001)
- Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts. Krasowski MD, Yasuda K, Hagey LR, Schuetz EG. Mol Endocrinol 19 1720-1739 (2005)
- Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism. Xue Y, Chao E, Zuercher WJ, Willson TM, Collins JL, Redinbo MR. Bioorg Med Chem 15 2156-2166 (2007)
- The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. Färnegårdh M, Bonn T, Sun S, Ljunggren J, Ahola H, Wilhelmsson A, Gustafsson JA, Carlquist M. J Biol Chem 278 38821-38828 (2003)
- Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein. Schumacher MA, Miller MC, Brennan RG. EMBO J 23 2923-2930 (2004)
- The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor. Wang H, Li H, Moore LB, Johnson MD, Maglich JM, Goodwin B, Ittoop OR, Wisely B, Creech K, Parks DJ, Collins JL, Willson TM, Kalpana GV, Venkatesh M, Xie W, Cho SY, Roboz J, Redinbo M, Moore JT, Mani S. Mol Endocrinol 22 838-857 (2008)
- Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements. Thompson PD, Jurutka PW, Whitfield GK, Myskowski SM, Eichhorst KR, Dominguez CE, Haussler CA, Haussler MR. Biochem Biophys Res Commun 299 730-738 (2002)
- Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative. Adachi R, Honma Y, Masuno H, Kawana K, Shimomura I, Yamada S, Makishima M. J Lipid Res 46 46-57 (2005)
- Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity. Greschik H, Flaig R, Renaud JP, Moras D. J Biol Chem 279 33639-33646 (2004)
- Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR. Ekins S, Kortagere S, Iyer M, Reschly EJ, Lill MA, Redinbo MR, Krasowski MD. PLoS Comput Biol 5 e1000594 (2009)
- Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR. Krasowski MD, Ni A, Hagey LR, Ekins S. Mol Cell Endocrinol 334 39-48 (2011)
- PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides. Coumoul X, Diry M, Barouki R. Biochem Pharmacol 64 1513-1519 (2002)
- Thyroxine-thyroid hormone receptor interactions. Sandler B, Webb P, Apriletti JW, Huber BR, Togashi M, Cunha Lima ST, Juric S, Nilsson S, Wagner R, Fletterick RJ, Baxter JD. J Biol Chem 279 55801-55808 (2004)
- Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation. Hernandez JP, Mota LC, Baldwin WS. Curr Pharmacogenomics Person Med 7 81-105 (2009)
- Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds. Delfosse V, Dendele B, Huet T, Grimaldi M, Boulahtouf A, Gerbal-Chaloin S, Beucher B, Roecklin D, Muller C, Rahmani R, Cavaillès V, Daujat-Chavanieu M, Vivat V, Pascussi JM, Balaguer P, Bourguet W. Nat Commun 6 8089 (2015)
- Identification of clinically used drugs that activate pregnane X receptors. Shukla SJ, Sakamuru S, Huang R, Moeller TA, Shinn P, Vanleer D, Auld DS, Austin CP, Xia M. Drug Metab Dispos 39 151-159 (2011)
- Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4. Jurutka PW, Thompson PD, Whitfield GK, Eichhorst KR, Hall N, Dominguez CE, Hsieh JC, Haussler CA, Haussler MR. J Cell Biochem 94 917-943 (2005)
- Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene. Igarashi M, Yogiashi Y, Mihara M, Takada I, Kitagawa H, Kato S. Mol Cell Biol 27 7947-7954 (2007)
- Endocrine disruptors induce cytochrome P450 by affecting transcriptional regulation via pregnane X receptor. Mikamo E, Harada S, Nishikawa J, Nishihara T. Toxicol Appl Pharmacol 193 66-72 (2003)
- Evolution of pharmacologic specificity in the pregnane X receptor. Ekins S, Reschly EJ, Hagey LR, Krasowski MD. BMC Evol Biol 8 103 (2008)
- Evolution of the bile salt nuclear receptor FXR in vertebrates. Reschly EJ, Ai N, Ekins S, Welsh WJ, Hagey LR, Hofmann AF, Krasowski MD. J Lipid Res 49 1577-1587 (2008)
- Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket. Loo TW, Bartlett MC, Clarke DM. Biochem J 396 537-545 (2006)
- Estrogens and antiestrogens activate hPXR. Mnif W, Pascussi JM, Pillon A, Escande A, Bartegi A, Nicolas JC, Cavaillès V, Duchesne MJ, Balaguer P. Toxicol Lett 170 19-29 (2007)
- SPA70 is a potent antagonist of human pregnane X receptor. Lin W, Wang YM, Chai SC, Lv L, Zheng J, Wu J, Zhang Q, Wang YD, Griffin PR, Chen T. Nat Commun 8 741 (2017)
- Dark chemical matter as a promising starting point for drug lead discovery. Wassermann AM, Lounkine E, Hoepfner D, Le Goff G, King FJ, Studer C, Peltier JM, Grippo ML, Prindle V, Tao J, Schuffenhauer A, Wallace IM, Chen S, Krastel P, Cobos-Correa A, Parker CN, Davies JW, Glick M. Nat Chem Biol 11 958-966 (2015)
- The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity. Yamamoto Y, Kawamoto T, Negishi M. Arch Biochem Biophys 409 207-211 (2003)
- Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liver. Jinno H, Tanaka-Kagawa T, Hanioka N, Ishida S, Saeki M, Soyama A, Itoda M, Nishimura T, Saito Y, Ozawa S, Ando M, Sawada J. Mol Pharmacol 65 496-502 (2004)
- Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes. Hariparsad N, Chu X, Yabut J, Labhart P, Hartley DP, Dai X, Evers R. Nucleic Acids Res 37 1160-1173 (2009)
- Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors). Krasowski MD, Yasuda K, Hagey LR, Schuetz EG. Nucl Recept 3 2 (2005)
- Nuclear receptors CAR and PXR in the regulation of hepatic metabolism. Tien ES, Negishi M. Xenobiotica 36 1152-1163 (2006)
- In silico prediction of pregnane X receptor activators by machine learning approaches. Ung CY, Li H, Yap CW, Chen YZ. Mol Pharmacol 71 158-168 (2007)
- Modulation of pregnane X receptor- and electrophile responsive element-mediated gene expression by dietary polyphenolic compounds. Kluth D, Banning A, Paur I, Blomhoff R, Brigelius-Flohé R. Free Radic Biol Med 42 315-325 (2007)
- Computational discovery of novel low micromolar human pregnane X receptor antagonists. Ekins S, Kholodovych V, Ai N, Sinz M, Gal J, Gera L, Welsh WJ, Bachmann K, Mani S. Mol Pharmacol 74 662-672 (2008)
- Identification of pregnane X receptor binding sites in the regulatory regions of genes involved in bile acid homeostasis. Frank C, Makkonen H, Dunlop TW, Matilainen M, Väisänen S, Carlberg C. J Mol Biol 346 505-519 (2005)
- Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor. Sahi J, Milad MA, Zheng X, Rose KA, Wang H, Stilgenbauer L, Gilbert D, Jolley S, Stern RH, LeCluyse EL. J Pharmacol Exp Ther 306 1027-1034 (2003)
- Structural basis of human pregnane X receptor activation by the hops constituent colupulone. Teotico DG, Bischof JJ, Peng L, Kliewer SA, Redinbo MR. Mol Pharmacol 74 1512-1520 (2008)
- Activation of transcription through the ligand-binding pocket of the orphan nuclear receptor ultraspiracle. Xu Y, Fang F, Chu Y, Jones D, Jones G. Eur J Biochem 269 6026-6036 (2002)
- Expression of PXR, CYP3A and MDR1 genes in liver of zebrafish. Bresolin T, de Freitas Rebelo M, Celso Dias Bainy A. Comp Biochem Physiol C Toxicol Pharmacol 140 403-407 (2005)
- Identification of amino acids in rat pregnane X receptor that determine species-specific activation. Tirona RG, Leake BF, Podust LM, Kim RB. Mol Pharmacol 65 36-44 (2004)
- Alternative splicing within the ligand binding domain of the human constitutive androstane receptor. Savkur RS, Wu Y, Bramlett KS, Wang M, Yao S, Perkins D, Totten M, Searfoss G, Ryan TP, Su EW, Burris TP. Mol Genet Metab 80 216-226 (2003)
- Role of the PXR gene locus in inflammatory bowel diseases. Martínez A, Márquez A, Mendoza J, Taxonera C, Fernández-Arquero M, Díaz-Rubio M, de la Concha EG, Urcelay E. Inflamm Bowel Dis 13 1484-1487 (2007)
- A concentration addition model for the activation of the constitutive androstane receptor by xenobiotic mixtures. Baldwin WS, Roling JA. Toxicol Sci 107 93-105 (2009)
- Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: remodelling the LBP with one side chain rotation. Ciesielski F, Rochel N, Moras D. J Steroid Biochem Mol Biol 103 235-242 (2007)
- Dose-dependent induction of cytochrome P450 (CYP) 3A4 and activation of pregnane X receptor by topiramate. Nallani SC, Glauser TA, Hariparsad N, Setchell K, Buckley DJ, Buckley AR, Desai PB. Epilepsia 44 1521-1528 (2003)
- Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1. Xie Y, Ke S, Ouyang N, He J, Xie W, Bedford MT, Tian Y. J Biol Chem 284 9199-9205 (2009)
- Machine learning methods and docking for predicting human pregnane X receptor activation. Khandelwal A, Krasowski MD, Reschly EJ, Sinz MW, Swaan PW, Ekins S. Chem Res Toxicol 21 1457-1467 (2008)
- Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals. Adachi R, Shulman AI, Yamamoto K, Shimomura I, Yamada S, Mangelsdorf DJ, Makishima M. Mol Endocrinol 18 43-52 (2004)
- The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha. Liu FJ, Song X, Yang D, Deng R, Yan B. Biochem J 409 243-250 (2008)
- Effect of simultaneous induction and inhibition of CYP3A by St John's Wort and ritonavir on CYP3A activity. Hafner V, Jäger M, Matthée AK, Ding R, Burhenne J, Haefeli WE, Mikus G. Clin Pharmacol Ther 87 191-196 (2010)
- Human PXR forms a tryptophan zipper-mediated homodimer. Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR. Biochemistry 45 8579-8589 (2006)
- Activation of steroid and xenobiotic receptor (SXR, NR1I2) and its orthologs in laboratory, toxicologic, and genome model species. Milnes MR, Garcia A, Grossman E, Grün F, Shiotsugu J, Tabb MM, Kawashima Y, Katsu Y, Watanabe H, Iguchi T, Blumberg B. Environ Health Perspect 116 880-885 (2008)
- Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays. Zhu Z, Kim S, Chen T, Lin JH, Bell A, Bryson J, Dubaquie Y, Yan N, Yanchunas J, Xie D, Stoffel R, Sinz M, Dickinson K. J Biomol Screen 9 533-540 (2004)
- Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist. Hoerer S, Schmid A, Heckel A, Budzinski RM, Nar H. J Mol Biol 334 853-861 (2003)
- Amino acids important for ligand specificity of the human constitutive androstane receptor. Jyrkkärinne J, Windshügel B, Mäkinen J, Ylisirniö M, Peräkylä M, Poso A, Sippl W, Honkakoski P. J Biol Chem 280 5960-5971 (2005)
- Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptor. Chen Y, Tang Y, Robbins GT, Nie D. J Pharmacol Exp Ther 334 999-1008 (2010)
- Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84). Haslam IS, Jones K, Coleman T, Simmons NL. Biochem Pharmacol 76 850-861 (2008)
- Structural and functional analysis of the human nuclear xenobiotic receptor PXR in complex with RXRα. Wallace BD, Betts L, Talmage G, Pollet RM, Holman NS, Redinbo MR. J Mol Biol 425 2561-2577 (2013)
- Structural insight into the constitutive repression function of the nuclear receptor Rev-erbbeta. Woo EJ, Jeong DG, Lim MY, Jun Kim S, Kim KJ, Yoon SM, Park BC, Ryu SE. J Mol Biol 373 735-744 (2007)
- Suppressor mutations in the transmembrane segments of P-glycoprotein promote maturation of processing mutants and disrupt a subset of drug-binding sites. Loo TW, Bartlett MC, Clarke DM. J Biol Chem 282 32043-32052 (2007)
- Attenuating pregnane X receptor (PXR) activation: a molecular modelling approach. Gao YD, Olson SH, Balkovec JM, Zhu Y, Royo I, Yabut J, Evers R, Tan EY, Tang W, Hartley DP, Mosley RT. Xenobiotica 37 124-138 (2007)
- Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells. Basseville A, Preisser L, de Carné Trécesson S, Boisdron-Celle M, Gamelin E, Coqueret O, Morel A. Mol Cancer 10 80 (2011)
- The ratio of constitutive androstane receptor to pregnane X receptor determines the activity of guggulsterone against the Cyp2b10 promoter. Ding X, Staudinger JL. J Pharmacol Exp Ther 314 120-127 (2005)
- Hybrid scoring and classification approaches to predict human pregnane X receptor activators. Kortagere S, Chekmarev D, Welsh WJ, Ekins S. Pharm Res 26 1001-1011 (2009)
- MicroRNA-140-3p enhances the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting pregnenolone X receptor. Li J, Zhao J, Wang H, Li X, Liu A, Qin Q, Li B. Onco Targets Ther 11 5885-5894 (2018)
- Photochemotherapeutic agent 8-methoxypsoralen induces cytochrome P450 3A4 and carboxylesterase HCE2: evidence on an involvement of the pregnane X receptor. Yang J, Yan B. Toxicol Sci 95 13-22 (2007)
- Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity. Lemaire G, Benod C, Nahoum V, Pillon A, Boussioux AM, Guichou JF, Subra G, Pascussi JM, Bourguet W, Chavanieu A, Balaguer P. Mol Pharmacol 72 572-581 (2007)
- Functional characterization of a novel polymorphism of pregnane X receptor, Q158K, in Chinese subjects. Lim YP, Liu CH, Shyu LJ, Huang JD. Pharmacogenet Genomics 15 337-341 (2005)
- Gene expression profiling in the liver of CD-1 mice to characterize the hepatotoxicity of triazole fungicides. Goetz AK, Bao W, Ren H, Schmid JE, Tully DB, Wood C, Rockett JC, Narotsky MG, Sun G, Lambert GR, Thai SF, Wolf DC, Nesnow S, Dix DJ. Toxicol Appl Pharmacol 215 274-284 (2006)
- Lipopolysaccharide and cecal ligation/puncture differentially affect the subcellular distribution of the pregnane X receptor but consistently cause suppression of its target genes CYP3A. Sachdeva K, Yan B, Chichester CO. Shock 19 469-474 (2003)
- Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study. Liu YH, Mo SL, Bi HC, Hu BF, Li CG, Wang YT, Huang L, Huang M, Duan W, Liu JP, Wei MQ, Zhou SF. Xenobiotica 41 259-280 (2011)
- Active nuclear receptors exhibit highly correlated AF-2 domain motions. Teotico DG, Frazier ML, Ding F, Dokholyan NV, Temple BR, Redinbo MR. PLoS Comput Biol 4 e1000111 (2008)
- Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability. Wang W, Prosise WW, Chen J, Taremi SS, Le HV, Madison V, Cui X, Thomas A, Cheng KC, Lesburg CA. Protein Eng Des Sel 21 425-433 (2008)
- Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation. Ostberg T, Bertilsson G, Jendeberg L, Berkenstam A, Uppenberg J. Eur J Biochem 269 4896-4904 (2002)
- Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation. Garg A, Zhao A, Erickson SL, Mukherjee S, Lau AJ, Alston L, Chang TK, Mani S, Hirota SA. J Pharmacol Exp Ther 359 91-101 (2016)
- Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors. De Marino S, Ummarino R, D'Auria MV, Chini MG, Bifulco G, Renga B, D'Amore C, Fiorucci S, Debitus C, Zampella A. J Med Chem 54 3065-3075 (2011)
- Towards a new age of virtual ADME/TOX and multidimensional drug discovery. Ekins S, Boulanger B, Swaan PW, Hupcey MA. J Comput Aided Mol Des 16 381-401 (2002)
- Regulation of drug resistance by human pregnane X receptor in breast cancer. Chen Y, Tang Y, Chen S, Nie D. Cancer Biol Ther 8 1265-1272 (2009)
- Rifampin and digoxin induction of MDR1 expression and function in human intestinal (T84) epithelial cells. Haslam IS, Jones K, Coleman T, Simmons NL. Br J Pharmacol 154 246-255 (2008)
- Dexamethasone transcriptionally increases the expression of the pregnane X receptor and synergistically enhances pyrethroid esfenvalerate in the induction of cytochrome P450 3A23. Shi D, Yang D, Yan B. Biochem Pharmacol 80 1274-1283 (2010)
- Gene regulation for the senescence marker protein DHEA-sulfotransferase by the xenobiotic-activated nuclear pregnane X receptor (PXR). Echchgadda I, Song CS, Oh TS, Cho SH, Rivera OJ, Chatterjee B. Mech Ageing Dev 125 733-745 (2004)
- Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening. Pan Y, Li L, Kim G, Ekins S, Wang H, Swaan PW. Drug Metab Dispos 39 337-344 (2011)
- Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis. Huang K, Mukherjee S, DesMarais V, Albanese JM, Rafti E, Draghi Ii A, Maher LA, Khanna KM, Mani S, Matson AP. Pediatr Res 83 1031-1040 (2018)
- Highly prevalent vitamin D deficiency and insufficiency in an urban cohort of HIV-infected men under care. Wasserman P, Rubin DS. AIDS Patient Care STDS 24 223-227 (2010)
- Interaction between vitamin D receptor and vitamin D ligands: two-dimensional alanine scanning mutational analysis. Choi M, Yamamoto K, Itoh T, Makishima M, Mangelsdorf DJ, Moras D, DeLuca HF, Yamada S. Chem Biol 10 261-270 (2003)
- The environmental estrogen, nonylphenol, activates the constitutive androstane receptor. Hernandez JP, Huang W, Chapman LM, Chua S, Moore DD, Baldwin WS. Toxicol Sci 98 416-426 (2007)
- The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals. Handschin C, Blättler S, Roth A, Looser R, Oscarson M, Kaufmann MR, Podvinec M, Gnerre C, Meyer UA. Nucl Recept 2 7 (2004)
- Dual action of oestrogens on the mouse constitutive androstane receptor. Mäkinen J, Reinisalo M, Niemi K, Viitala P, Jyrkkärinne J, Chung H, Pelkonen O, Honkakoski P. Biochem J 376 465-472 (2003)
- Identification of novel activators of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches. Lynch C, Pan Y, Li L, Ferguson SS, Xia M, Swaan PW, Wang H. Pharm Res 30 489-501 (2013)
- Optimal drug cocktail design: methods for targeting molecular ensembles and insights from theoretical model systems. Radhakrishnan ML, Tidor B. J Chem Inf Model 48 1055-1073 (2008)
- The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation. Lin YS, Yasuda K, Assem M, Cline C, Barber J, Li CW, Kholodovych V, Ai N, Chen JD, Welsh WJ, Ekins S, Schuetz EG. Drug Metab Dispos 37 1295-1304 (2009)
- Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptor. van Giersbergen PL, Gnerre C, Treiber A, Dingemanse J, Meyer UA. Eur J Pharmacol 450 115-121 (2002)
- Evaluation of in vitro PXR-based assays and in silico modeling approaches for understanding the binding of a structurally diverse set of drugs to PXR. Xiao L, Nickbarg E, Wang W, Thomas A, Ziebell M, Prosise WW, Lesburg CA, Taremi SS, Gerlach VL, Le HV, Cheng KC. Biochem Pharmacol 81 669-679 (2011)
- Quantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor. Lynch C, Zhao J, Huang R, Xiao J, Li L, Heyward S, Xia M, Wang H. Sci Rep 5 10405 (2015)
- Characterization of porcine pregnane X receptor, farnesoid X receptor and their splice variants. Gray MA, Pollock CB, Schook LB, Squires EJ. Exp Biol Med (Maywood) 235 718-736 (2010)
- Structural model reveals key interactions in the assembly of the pregnane X receptor/corepressor complex. Wang CY, Li CW, Chen JD, Welsh WJ. Mol Pharmacol 69 1513-1517 (2006)
- The critical role of carboxy-terminal amino acids in ligand-dependent and -independent transactivation of the constitutive androstane receptor. Andersin T, Väisänen S, Carlberg C. Mol Endocrinol 17 234-246 (2003)
- The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species. Krasowski MD, Ai N, Hagey LR, Kollitz EM, Kullman SW, Reschly EJ, Ekins S. BMC Biochem 12 5 (2011)
- A zinc-binding dual-specificity YVH1 phosphatase in the malaria parasite, Plasmodium falciparum, and its interaction with the nuclear protein, pescadillo. Kumar R, Musiyenko A, Cioffi E, Oldenburg A, Adams B, Bitko V, Krishna SS, Barik S. Mol Biochem Parasitol 133 297-310 (2004)
- Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor. Li L, Welch MA, Li Z, Mackowiak B, Heyward S, Swaan PW, Wang H. Mol Pharmacol 96 345-354 (2019)
- Milk thistle's active components silybin and isosilybin: novel inhibitors of PXR-mediated CYP3A4 induction. Mooiman KD, Maas-Bakker RF, Moret EE, Beijnen JH, Schellens JH, Meijerman I. Drug Metab Dispos 41 1494-1504 (2013)
- Tamoxifen activates CYP3A4 and MDR1 genes through steroid and xenobiotic receptor in breast cancer cells. Nagaoka R, Iwasaki T, Rokutanda N, Takeshita A, Koibuchi Y, Horiguchi J, Shimokawa N, Iino Y, Morishita Y, Koibuchi N. Endocrine 30 261-268 (2006)
- Thermodynamic characterization of the interaction between CAR-RXR and SRC-1 peptide by isothermal titration calorimetry. Wright E, Vincent J, Fernandez EJ. Biochemistry 46 862-870 (2007)
- Casein Kinase 2 (CK2)-mediated Phosphorylation of Hsp90β as a Novel Mechanism of Rifampin-induced MDR1 Expression. Kim SW, Hasanuzzaman M, Cho M, Heo YR, Ryu MJ, Ha NY, Park HJ, Park HY, Shin JG. J Biol Chem 290 17029-17040 (2015)
- Evolutionary history and functional characterization of the amphibian xenosensor CAR. Mathäs M, Burk O, Qiu H, Nusshag C, Gödtel-Armbrust U, Baranyai D, Deng S, Römer K, Nem D, Windshügel B, Wojnowski L. Mol Endocrinol 26 14-26 (2012)
- Role of 14-3-3 sigma in over-expression of P-gp by rifampin and paclitaxel stimulation through interaction with PXR. Kim SW, Md Hasanuzzaman, Cho M, Kim NH, Choi HY, Han JW, Park HJ, Oh JW, Shin JG. Cell Signal 31 124-134 (2017)
- Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation. Lim YP, Ma CY, Liu CL, Lin YH, Hu ML, Chen JJ, Hung DZ, Hsieh WT, Huang JD. Evid Based Complement Alternat Med 2012 242810 (2012)
- Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721. Cheng Y, Redinbo MR. Protein Sci 20 1713-1719 (2011)
- Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor. Ratajewski M, Walczak-Drzewiecka A, Sałkowska A, Dastych J. Toxicol Lett 205 146-153 (2011)
- Application and interpretation of hPXR screening data: Validation of reporter signal requirements for prediction of clinically relevant CYP3A4 inducers. Cui X, Thomas A, Gerlach V, White RE, Morrison RA, Cheng KC. Biochem Pharmacol 76 680-689 (2008)
- Human monocyte-derived cells with individual hepatocyte characteristics: a novel tool for personalized in vitro studies. Benesic A, Rahm NL, Ernst S, Gerbes AL. Lab Invest 92 926-936 (2012)
- The role of residues T248, Y249 and T422 in the function of human pregnane X receptor. Doricakova A, Novotna A, Vrzal R, Pavek P, Dvorak Z. Arch Toxicol 87 291-301 (2013)
- A molecular switch regulating transcriptional repression and activation of PPARγ. Shang J, Mosure SA, Zheng J, Brust R, Bass J, Nichols A, Solt LA, Griffin PR, Kojetin DJ. Nat Commun 11 956 (2020)
- A pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development. Mu Y, Stephenson CR, Kendall C, Saini SP, Toma D, Ren S, Cai H, Strom SC, Day BW, Wipf P, Xie W. Mol Pharmacol 68 403-413 (2005)
- Development of BODIPY FL vindoline as a novel and high-affinity pregnane X receptor fluorescent probe. Lin W, Liu J, Jeffries C, Yang L, Lu Y, Lee RE, Chen T. Bioconjug Chem 25 1664-1677 (2014)
- Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor. Banerjee M, Chen T. Biochem Pharmacol 86 824-835 (2013)
- Drug-induced changes in P450 enzyme expression at the gene expression level: a new dimension to the analysis of drug-drug interactions. Lee MD, Ayanoglu E, Gong L. Xenobiotica 36 1013-1080 (2006)
- Ligand unbinding from the estrogen receptor: a computational study of pathways and ligand specificity. Burendahl S, Danciulescu C, Nilsson L. Proteins 77 842-856 (2009)
- Simultaneous substitution of phenylalanine-305 and aspartate-318 of rat pregnane X receptor with the corresponding human residues abolishes the ability to transactivate the CYP3A23 promoter. Song X, Li Y, Liu J, Mukundan M, Yan B. J Pharmacol Exp Ther 312 571-582 (2005)
- Structurally and functionally important amino acids of the agonistic conformation of the human vitamin D receptor. Väisänen S, Ryhänen S, Saarela JT, Peräkylä M, Andersin T, Mäenpää PH. Mol Pharmacol 62 788-794 (2002)
- Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei. De Marino S, Sepe V, D'Auria MV, Bifulco G, Renga B, Petek S, Fiorucci S, Zampella A. Org Biomol Chem 9 4856-4862 (2011)
- Agonist-dependent and agonist-independent transactivations of the human constitutive androstane receptor are modulated by specific amino acid pairs. Frank C, Molnár F, Matilainen M, Lempiäinen H, Carlberg C. J Biol Chem 279 33558-33566 (2004)
- Effects of Vitamin K₂ on the Expression of Genes Involved in Bile Acid Synthesis and Glucose Homeostasis in Mice with Humanized PXR. Sultana H, Watanabe K, Rana MM, Takashima R, Ohashi A, Komai M, Shirakawa H. Nutrients 10 (2018)
- Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in zebrafish (Danio rerio). Bainy AC, Kubota A, Goldstone JV, Lille-Langøy R, Karchner SI, Celander MC, Hahn ME, Goksøyr A, Stegeman JJ. Aquat Toxicol 142-143 447-457 (2013)
- Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning. Huber AD, Wright WC, Lin W, Majumder K, Low JA, Wu J, Buchman CD, Pintel DJ, Chen T. Cell Mol Life Sci 78 317-335 (2021)
- Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes suggests that hPXR is less sensitive than mouse PXR to nonylphenol treatment. Mota LC, Barfield C, Hernandez JP, Baldwin WS. Toxicol Appl Pharmacol 252 259-267 (2011)
- Pregnane X receptor polymorphism affects CYP3A4 induction via a ligand-dependent interaction with steroid receptor coactivator-1. Lim YP, Huang JD. Pharmacogenet Genomics 17 369-382 (2007)
- Rifampicin-independent interactions between the pregnane X receptor ligand binding domain and peptide fragments of coactivator and corepressor proteins. Navaratnarajah P, Steele BL, Redinbo MR, Thompson NL. Biochemistry 51 19-31 (2012)
- Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently. Lille-Langøy R, Goldstone JV, Rusten M, Milnes MR, Male R, Stegeman JJ, Blumberg B, Goksøyr A. Toxicol Appl Pharmacol 284 54-64 (2015)
- Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase. Oladimeji PO, Lin W, Brewer CT, Chen T. Sci Rep 7 46751 (2017)
- Thr176 regulates the activity of the mouse nuclear receptor CAR and is conserved in the NR1I subfamily members PXR and VDR. Ueda A, Matsui K, Yamamoto Y, Pedersen LC, Sueyoshi T, Negishi M. Biochem J 388 623-630 (2005)
- A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrile. Bailey I, Gibson GG, Plant K, Graham M, Plant N. PLoS One 6 e16703 (2011)
- Activation of a tunicate (Ciona intestinalis) xenobiotic receptor orthologue by both natural toxins and synthetic toxicants. Fidler AE, Holland PT, Reschly EJ, Ekins S, Krasowski MD. Toxicon 59 365-372 (2012)
- Comparative genomics of xenobiotic metabolism: a porcine-human PXR gene comparison. Pollock CB, Rogatcheva MB, Schook LB. Mamm Genome 18 210-219 (2007)
- Development of humanized steroid and xenobiotic receptor mouse by homologous knock-in of the human steroid and xenobiotic receptor ligand binding domain sequence. Igarashi K, Kitajima S, Aisaki K, Tanemura K, Taquahashi Y, Moriyama N, Ikeno E, Matsuda N, Saga Y, Blumberg B, Kanno J. J Toxicol Sci 37 373-380 (2012)
- Development of in silico filters to predict activation of the pregnane X receptor (PXR) by structurally diverse drug-like molecules. Matter H, Anger LT, Giegerich C, Güssregen S, Hessler G, Baringhaus KH. Bioorg Med Chem 20 5352-5365 (2012)
- In vivo activation of the human CYP3A4 promoter in mouse liver and regulation by pregnane X receptors. Zhang W, Purchio A, Chen K, Burns SM, Contag CH, Contag PR. Biochem Pharmacol 65 1889-1896 (2003)
- Induction of CYP3A by 2,3-oxidosqualene:lanosterol cyclase inhibitors is mediated by an endogenous squalene metabolite in primary cultured rat hepatocytes. Shenoy SD, Spencer TA, Mercer-Haines NA, Abdolalipour M, Wurster WL, Runge-Morris M, Kocarek TA. Mol Pharmacol 65 1302-1312 (2004)
- Inhibitors or toxins? Large library target-specific screening of fullerene-based nanoparticles for drug design purpose. Ahmed L, Rasulev B, Kar S, Krupa P, Mozolewska MA, Leszczynski J. Nanoscale 9 10263-10276 (2017)
- A Molecular Aspect in the Regulation of Drug Metabolism: Does PXR-Induced Enzyme Expression Always Lead to Functional Changes in Drug Metabolism? Wei Y, Tang C, Sant V, Li S, Poloyac SM, Xie W. Curr Pharmacol Rep 2 187-192 (2016)
- Cholesterol detoxification by the nuclear pregnane X receptor. Kliewer SA. Proc Natl Acad Sci U S A 102 2675-2676 (2005)
- Comparative In Vitro and In Silico Analysis of the Selectivity of Indirubin as a Human Ah Receptor Agonist. Faber SC, Soshilov AA, Giani Tagliabue S, Bonati L, Denison MS. Int J Mol Sci 19 E2692 (2018)
- Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity. Windshügel B, Jyrkkärinne J, Poso A, Honkakoski P, Sippl W. J Mol Model 11 69-79 (2005)
- Oxazaphosphorine bioactivation and detoxification The role of xenobiotic receptors. Wang D, Wang H. Acta Pharm Sin B 2 (2012)
- SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors. Zimmermann K, Wittman MD, Saulnier MG, Velaparthi U, Sang X, Frennesson DB, Struzynski C, Seitz SP, He L, Carboni JM, Li A, Greer AF, Gottardis M, Attar RM, Yang Z, Balimane P, Discenza LN, Lee FY, Sinz M, Kim S, Vyas D. Bioorg Med Chem Lett 20 1744-1748 (2010)
- Comment A response to reimportation. Newcomer M. Structure 13 1-2 (2005)
- A vinblastine fluorescent probe for pregnane X receptor in a time-resolved fluorescence resonance energy transfer assay. Lin W, Chen T. Anal Biochem 443 252-260 (2013)
- AutoMap: a tool for analyzing protein-ligand recognition using multiple ligand binding modes. Agostino M, Mancera RL, Ramsland PA, Yuriev E. J Mol Graph Model 40 80-90 (2013)
- Critical role of charged residues in helix 7 of the ligand binding domain in Hepatocyte Nuclear Factor 4alpha dimerisation and transcriptional activity. Eeckhoute J, Oxombre B, Formstecher P, Lefebvre P, Laine B. Nucleic Acids Res 31 6640-6650 (2003)
- Developing Adnectins that target SRC co-activator binding to PXR: a structural approach toward understanding promiscuity of PXR. Khan JA, Camac DM, Low S, Tebben AJ, Wensel DL, Wright MC, Su J, Jenny V, Gupta RD, Ruzanov M, Russo KA, Bell A, An Y, Bryson JW, Gao M, Gambhire P, Baldwin ET, Gardner D, Cavallaro CL, Duncia JV, Hynes J. J Mol Biol 427 924-942 (2015)
- Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors. Musille PM, Pathak M, Lauer JL, Griffin PR, Ortlund EA. J Biol Chem 288 20702-20712 (2013)
- Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics. Maldonado EM, Leoncikas V, Fisher CP, Moore JB, Plant NJ, Kierzek AM. CPT Pharmacometrics Syst Pharmacol 6 732-746 (2017)
- Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding. Banerjee M, Chai SC, Wu J, Robbins D, Chen T. Biochem Pharmacol 104 131-138 (2016)
- Unique transcription start sites and distinct promoter regions differentiate the pregnane X receptor (PXR) isoforms PXR 1 and PXR 2. Tompkins LM, Sit TL, Wallace AD. Drug Metab Dispos 36 923-929 (2008)
- A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity. Peters KM, Brooks BE, Schumacher MA, Skurray RA, Brennan RG, Brown MH. PLoS One 6 e15974 (2011)
- Analysis of flavonoids regulating the expression of UGT1A1 via xenobiotic receptors in intestinal epithelial cells. Hiura Y, Satsu H, Hamada M, Shimizu M. Biofactors 40 336-345 (2014)
- CONSERVED AND EXAPTED FUNCTIONS OF NUCLEAR RECEPTORS IN ANIMAL DEVELOPMENT. Bodofsky S, Koitz F, Wightman B. Nucl Receptor Res 4 101305 (2017)
- Differential effects of raloxifene, tamoxifen and fulvestrant on a murine mammary carcinoma. Lamb CA, Helguero LA, Fabris V, Lucas C, Molinolo AA, Lanari C. Breast Cancer Res Treat 79 25-35 (2003)
- Direct detection of structurally resolved dynamics in a multiconformation receptor-ligand complex. Carroll MJ, Gromova AV, Miller KR, Tang H, Wang XS, Tripathy A, Singleton SF, Collins EJ, Lee AL. J Am Chem Soc 133 6422-6428 (2011)
- Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges. Sepe V, D'Amore C, Ummarino R, Renga B, D'Auria MV, Novellino E, Sinisi A, Taglialatela-Scafati O, Nakao Y, Limongelli V, Zampella A, Fiorucci S. Eur J Med Chem 73 126-134 (2014)
- Preferential physical and functional interaction of pregnane X receptor with the SMRTalpha isoform. Li CW, Dinh GK, Chen JD. Mol Pharmacol 75 363-373 (2009)
- Chemical complementation: small-molecule-based genetic selection in yeast. Azizi B, Chang EI, Doyle DF. Biochem Biophys Res Commun 306 774-780 (2003)
- Clofibrate and perfluorodecanoate both upregulate the expression of the pregnane X receptor but oppositely affect its ligand-dependent induction on cytochrome P450 3A23. Ma Y, Sachdeva K, Liu J, Song X, Li Y, Yang D, Deng R, Chichester CO, Yan B. Biochem Pharmacol 69 1363-1371 (2005)
- Crystal structure of YfiR, an unusual TetR/CamR-type putative transcriptional regulator from Bacillus subtilis. Rajan SS, Yang X, Shuvalova L, Collart F, Anderson WF. Proteins 65 255-257 (2006)
- Cyclic AMP-independent activation of CYP3A4 gene expression by forskolin. Dowless MS, Barbee JL, Borchert KM, Bocchinfuso WP, Houck KA. Eur J Pharmacol 512 9-13 (2005)
- Insecticide detoxification indicator strains as tools for enhancing chemical discovery screens. Shah S, Yarrow C, Dunning R, Cheek B, Vass S, Windass J, Hadfield S. Pest Manag Sci 68 38-48 (2012)
- Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist. Sepe V, Ummarino R, D'Auria MV, Lauro G, Bifulco G, D'Amore C, Renga B, Fiorucci S, Zampella A. Org Biomol Chem 10 6350-6362 (2012)
- Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis. Flora GD, Sahli KA, Sasikumar P, Holbrook LM, Stainer AR, AlOuda SK, Crescente M, Sage T, Unsworth AJ, Gibbins JM. Sci Rep 9 17210 (2019)
- Specificity in molecular design: a physical framework for probing the determinants of binding specificity and promiscuity in a biological environment. Radhakrishnan ML, Tidor B. J Phys Chem B 111 13419-13435 (2007)
- Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzyme. Singh RK, Suzuki T, Mandal T, Balsubramanian N, Haldar M, Mueller DJ, Strode JA, Cook G, Mallik S, Srivastava DK. Biochemistry 53 7445-7458 (2014)
- Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1. Banerjee M, Chen T. Biochem Pharmacol 92 389-402 (2014)
- Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons. Küblbeck J, Zancanella V, Prantner V, Molnár F, Squires EJ, Dacasto M, Honkakoski P, Giantin M. Xenobiotica 46 200-210 (2016)
- Mitotane induces CYP3A4 expression via activation of the steroid and xenobiotic receptor. Takeshita A, Igarashi-Migitaka J, Koibuchi N, Takeuchi Y. J Endocrinol 216 297-305 (2013)
- Oleanolic Acid and Ursolic Acid Induce UGT1A1 Expression in HepG2 Cells by Activating PXR Rather Than CAR. Yao N, Zeng C, Zhan T, He F, Liu M, Liu F, Zhang H, Xiong Y, Xia C. Front Pharmacol 10 1111 (2019)
- Congress Orphan nuclear receptors, PXR and LXR: new ligands and therapeutic potential. Gong H, Xie W. Expert Opin Ther Targets 8 49-54 (2004)
- News The PXR ligand-binding domain: how to be picky and promiscuous at the same time. Gillam EM. Trends Pharmacol Sci 22 448 (2001)
- The novel antibacterial compound walrycin A induces human PXR transcriptional activity. Berthier A, Oger F, Gheeraert C, Boulahtouf A, Le Guével R, Balaguer P, Staels B, Salbert G, Lefebvre P. Toxicol Sci 127 225-235 (2012)
- Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells. Kim HM, Kim JW, Choi Y, Chun HS, Im I, Han YM, Song CW, Yoon S, Park HJ. Sci Rep 6 21684 (2016)
- Augmentation of estrogen receptor-mediated transcription by steroid and xenobiotic receptor. Rokutanda N, Iwasaki T, Odawara H, Nagaoka R, Miyazaki W, Takeshita A, Koibuchi Y, Horiguchi J, Shimokawa N, Iino Y, Morishita Y, Koibuchi N. Endocrine 33 305-316 (2008)
- High-throughput evaluation method for drug association with pregnane X receptor (PXR) using differential scanning fluorometry. Sekiguchi M, Kobashigawa Y, Moriguchi H, Kawasaki M, Yuda M, Teramura T, Inagaki F. J Biomol Screen 18 1084-1091 (2013)
- In Silico Prediction of hPXR Activators Using Structure-Based Pharmacophore Modeling. Torimoto-Katori N, Huang R, Kato H, Ohashi R, Xia M. J Pharm Sci 106 1752-1759 (2017)
- Nuclear xeno-sensors as receptors for cholestatic bile acids: the second line of defense. Bock HH, Lammert F. Hepatology 35 232-234 (2002)
- Phosphorylation Modulates the Coregulatory Protein Exchange of the Nuclear Receptor Pregnane X Receptor. Cui W, Shen X, Agbas E, Tompkins B, Cameron-Carter H, Staudinger JL. J Pharmacol Exp Ther 373 370-380 (2020)
- Role of pregnane xenobiotic receptor in the midbrain ventral tegmental area for estradiol- and 3α,5α-THP-facilitated lordosis of female rats. Frye CA, Koonce CJ, Walf AA. Psychopharmacology (Berl) 231 3365-3374 (2014)
- Advances in predicting CYP-mediated drug interactions in the drug discovery setting. Wahlstrom JL, Rock DA, Slatter JG, Wienkers LC. Expert Opin Drug Discov 1 677-691 (2006)
- Affinity purification using recombinant PXR as a tool to characterize environmental ligands. Dagnino S, Bellet V, Grimaldi M, Riu A, Aït-Aïssa S, Cavaillès V, Fenet H, Balaguer P. Environ Toxicol 29 207-215 (2014)
- Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes. Yang J, Luan X, Gui H, Yan P, Yang D, Song X, Liu W, Hu G, Yan B. Br J Pharmacol 162 441-451 (2011)
- Conformational landscapes for KMSKS loop in tyrosyl-tRNA synthetases. Datt M, Sharma A. J Struct Funct Genomics 15 45-61 (2014)
- Detection of marine microalgal biotoxins using bioassays based on functional expression of tunicate xenobiotic receptors in yeast. Richter I, Fidler AE. Toxicon 95 13-22 (2015)
- Effect of Vitamin K-Mediated PXR Activation on Drug-Metabolizing Gene Expression in Human Intestinal Carcinoma LS180 Cell Line. Sultana H, Kato A, Ohashi A, Takashima R, Katsurai T, Sato S, Monma M, Ohsaki Y, Goto T, Komai M, Shirakawa H. Nutrients 13 1709 (2021)
- Exploration of the conformational landscape in pregnane X receptor reveals a new binding pocket. Chandran A, Vishveshwara S. Protein Sci 25 1989-2005 (2016)
- Human pregnane X receptor activation and CYP3A4/CYP2B6 induction by 2,3-oxidosqualene:lanosterol cyclase inhibition. Duniec-Dmuchowski Z, Fang HL, Strom SC, Ellis E, Runge-Morris M, Kocarek TA. Drug Metab Dispos 37 900-908 (2009)
- Indirubin-pregnane X receptor-JNK axis accelerates skin wound healing. Tanaka Y, Uchi H, Ito T, Furue M. Sci Rep 9 18174 (2019)
- No activation of human pregnane X receptor by hyperforin-related phloroglucinols. Kandel BA, Ekins S, Leuner K, Thasler WE, Harteneck C, Zanger UM. J Pharmacol Exp Ther 348 393-400 (2014)
- Pattern recognition and massively distributed computing. Davies EK, Glick M, Harrison KN, Richards WG. J Comput Chem 23 1544-1550 (2002)
- A structural signature motif enlightens the origin and diversification of nuclear receptors. Beinsteiner B, Markov GV, Erb S, Chebaro Y, McEwen AG, Cianférani S, Laudet V, Moras D, Billas IML. PLoS Genet 17 e1009492 (2021)
- Bile Acids-A Peek Into Their History and Signaling. Nguyen JT, Shaw RPH, Anakk S. Endocrinology 163 bqac155 (2022)
- Commentary: Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition! Pollet M, Krutmann J, Haarmann-Stemmann T. Front Pharmacol 9 935 (2018)
- Crystal structure of a putative HTH-type transcriptional regulator yxaF from Bacillus subtilis. Seetharaman J, Kumaran D, Bonanno JB, Burley SK, Swaminathan S. Proteins 63 1087-1091 (2006)
- Development of a quantitative model of pregnane X receptor (PXR) mediated xenobiotic metabolizing enzyme induction. Luke NS, DeVito MJ, Shah I, El-Masri HA. Bull Math Biol 72 1799-1819 (2010)
- Evaluation of Ginkgo biloba extract as an activator of human glucocorticoid receptor. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TK. J Ethnopharmacol 145 670-675 (2013)
- Exploring the Carbamazepine Interaction with Human Pregnane X Receptor and Effect on ABCC2 Using in Vitro and in Silico Approach. Grewal GK, Singh KD, Kanojia N, Rawat C, Kukal S, Jajodia A, Singhal A, Misra R, Nagamani S, Muthusamy K, Kukreti R. Pharm Res 34 1444-1458 (2017)
- Helix 12 stabilization contributes to basal transcriptional activity of PXR. Shizu R, Nishiguchi H, Tashiro S, Sato T, Sugawara A, Kanno Y, Hosaka T, Sasaki T, Yoshinari K. J Biol Chem 297 100978 (2021)
- Induction of human cytochrome P450 3A4 by the irreversible myeloperoxidase inactivator PF-06282999 is mediated by the pregnane X receptor. Moscovitz JE, Lin Z, Johnson N, Tu M, Goosen TC, Weng Y, Kalgutkar AS. Xenobiotica 48 647-655 (2018)
- Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems. Honma M, Kozawa M, Suzuki H. Expert Opin Drug Discov 5 491-511 (2010)
- Molecular modelling of the human glucocorticoid receptor (hGR) ligand-binding domain (LBD) by homology with the human estrogen receptor alpha (hERalpha) LBD: quantitative structure-activity relationships within a series of CYP3A4 inducers where induction is mediated via hGR involvement. Lewis DF, Ogg MS, Goldfarb PS, Gibson GG. J Steroid Biochem Mol Biol 82 195-199 (2002)
- Organotin compound DBDCT induces CYP3A suppression through NF-κB-mediated repression of PXR activity. Li Y, Lin N, Ji X, Mai J, Li Q. Metallomics 11 936-948 (2019)
- Predicting activation of the promiscuous human pregnane X receptor by pharmacophore ensemble/support vector machine approach. Chen CN, Shih YH, Ding YL, Leong MK. Chem Res Toxicol 24 1765-1778 (2011)
- X-ray crystal structure of the ancestral 3-ketosteroid receptor-progesterone-mifepristone complex shows mifepristone bound at the coactivator binding interface. Colucci JK, Ortlund EA. PLoS One 8 e80761 (2013)
- Design and synthesis of lactam-thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors. Barnes-Seeman D, Boiselle C, Capacci-Daniel C, Chopra R, Hoffmaster K, Jones CT, Kato M, Lin K, Ma S, Pan G, Shu L, Wang J, Whiteman L, Xu M, Zheng R, Fu J. Bioorg Med Chem Lett 24 3979-3985 (2014)
- In silico prediction of inhibition of promiscuous breast cancer resistance protein (BCRP/ABCG2). Ding YL, Shih YH, Tsai FY, Leong MK. PLoS One 9 e90689 (2014)
- Predictive models for identifying the binding activity of structurally diverse chemicals to human pregnane X receptor. Yin C, Yang X, Wei M, Liu H. Environ Sci Pollut Res Int 24 20063-20071 (2017)
- Probing Ligand Structure-Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8-Hydroxyefavirenz Exhibit Divergence in Activation. Narayanan B, Lade JM, Heck CJS, Dietz KD, Wade H, Bumpus NN. ChemMedChem 13 736-747 (2018)
- Treatment of cardiovascular disease by traditional Chinese medicine against pregnane X receptor. Chen KB, Chen HY, Chen KC, Chen CY. Biomed Res Int 2014 950191 (2014)
- Effects of Oridonin on Hepatic Cytochrome P450 Expression and Activities in PXR-Humanized Mice. Yi-Wen Z, Mei-Hua B, Xiao-Ya L, Yu C, Jing Y, Hong-Hao Z. Biol Pharm Bull 41 707-712 (2018)
- Expression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanised livers. Uehara S, Higuchi Y, Yoneda N, Yamazaki H, Suemizu H. Xenobiotica 49 678-687 (2019)
- In silico investigation of agonist activity of a structurally diverse set of drugs to hPXR using HM-BSM and HM-PNN. Zhang YM, Chang MJ, Yang XS, Han X. J Huazhong Univ Sci Technolog Med Sci 36 463-468 (2016)
- Lathyrane Diterpenoids as Novel hPXR Agonists: Isolation, Structural Modification, and Structure-Activity Relationships. Huang D, Wang RM, Li W, Zhao YY, Yuan FY, Yan XL, Chen Y, Tang GH, Bi HC, Yin S. ACS Med Chem Lett 12 1159-1165 (2021)
- Molecular insights into the promiscuous interaction of human pregnane X receptor (hPXR) with diverse environmental chemicals and drug compounds. Chen S, He N, Chen W, Sun F, Li L, Deng R, Hu Y. Chemosphere 96 138-145 (2014)
- Organoid-derived intestinal epithelial cells are a suitable model for preclinical toxicology and pharmacokinetic studies. Takahashi Y, Noguchi M, Inoue Y, Sato S, Shimizu M, Kojima H, Okabe T, Kiyono H, Yamauchi Y, Sato R. iScience 25 104542 (2022)
- PXR ligand classification model with SFED-weighted WHIM and CoMMA descriptors. Ma SL, Joung JY, Lee S, Cho KH, No KT. SAR QSAR Environ Res 23 485-504 (2012)
- Phase 0 of the Xenobiotic Response: Nuclear Receptors and Other Transcription Factors as a First Step in Protection from Xenobiotics. Baldwin WS. Nucl Receptor Res 6 101447 (2019)
- Structure-activity relationship modeling for predicting interactions with pregnane X receptor by recursive partitioning. Yoshida S, Yamashita F, Itoh T, Hashida M. Drug Metab Pharmacokinet 27 506-512 (2012)
- Validation of the cell line LS180 as a model for study of the gastrointestinal toxicity of mycophenolic acid. Heischmann S, Christians U. Xenobiotica 48 433-441 (2018)
- Development and Experimental Validation of Regularized Machine Learning Models Detecting New, Structurally Distinct Activators of PXR. Hirte S, Burk O, Tahir A, Schwab M, Windshügel B, Kirchmair J. Cells 11 1253 (2022)
- Multiple drugs and multiple targets: an analysis of the electrostatic determinants of binding between non-nucleoside HIV-1 reverse transcriptase inhibitors and variants of HIV-1 RT. Minkara MS, Davis PH, Radhakrishnan ML. Proteins 80 573-590 (2012)
- Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity. Huang D, Zhao YY, Wang RM, Li W, Yuan FY, Yan XL, Yang X, Tang GH, Yin S, Bi HC. Acta Pharmacol Sin 43 2139-2146 (2022)
- Protecting against cocaine, heroin, and sarin gas. McRee D. Chem Biol 10 295-297 (2003)
- Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptor. Mathäs M, Nusshag C, Burk O, Gödtel-Armbrust U, Herlyn H, Wojnowski L, Windshügel B. PLoS One 9 e96263 (2014)
- Structural overview and perspectives of the nuclear receptors, a major family as the direct targets for small-molecule drugs. Li F, Song C, Zhang Y, Wu D. Acta Biochim Biophys Sin (Shanghai) 54 12-24 (2022)
- Crystallographic analysis of murine constitutive androstane receptor ligand-binding domain complexed with 5alpha-androst-16-en-3alpha-ol. Vincent J, Shan L, Fan M, Brunzelle JS, Forman BM, Fernandez EJ. Acta Crystallogr Sect F Struct Biol Cryst Commun 61 156-159 (2005)
- Design and Optimization of 1H-1,2,3-Triazole-4-carboxamides as Novel, Potent, and Selective Inverse Agonists and Antagonists of PXR. Li Y, Lin W, Chai SC, Wu J, Annu K, Chen T. J Med Chem 65 16829-16859 (2022)
- Discrepancy in interactions and conformational dynamics of pregnane X receptor (PXR) bound to an agonist and a novel competitive antagonist. Rashidian A, Mustonen EK, Kronenberger T, Schwab M, Burk O, Laufer SA, Pantsar T. Comput Struct Biotechnol J 20 3004-3018 (2022)
- Effect of Gut Microbiota on the Pharmacokinetics of Nifedipine in Spontaneously Hypertensive Rats. Zhou R, Yang H, Zhu P, Liu Y, Zhang Y, Zhang W, Zhou H, Li X, Li Q. Pharmaceutics 15 2085 (2023)
- Okadaic acid influences xenobiotic metabolism in HepaRG cells. Wuerger LTD, Hammer HS, Hofmann U, Kudiabor F, Sieg H, Braeuning A. EXCLI J 21 1053-1065 (2022)
- Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction. Ramanjulu JM, Williams SP, Lakdawala AS, DeMartino MP, Lan Y, Marquis RW. ACS Med Chem Lett 12 1396-1404 (2021)
- Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions. Fan S, Yan Y, Xia Y, Zhou Z, Luo L, Zhu M, Han Y, Yao D, Zhang L, Fang M, Peng L, Yu J, Liu Y, Gao X, Guan H, Li H, Wang C, Wu X, Zhu H, Cao Y, Huang C. Nat Commun 14 3368 (2023)
- Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein. Lin W, Huber AD, Poudel S, Li Y, Seetharaman J, Miller DJ, Chen T. Proc Natl Acad Sci U S A 120 e2217804120 (2023)
- The conformational dynamics of H2-H3n and S2-H6 in gating ligand entry into the buried binding cavity of vitamin D receptor. Tee WV, Ripen AM, Mohamad SB. Sci Rep 6 35937 (2016)