› 1ijx

X-ray diffraction
1.9Å resolution

CRYSTAL STRUCTURE OF THE CYSTEINE-RICH DOMAIN OF SECRETED FRIZZLED-RELATED PROTEIN 3 (SFRP-3;FZB)

Released:
DOI: 10.2210/pdb1ijx/pdb
PDB entry 1ijx coloured by chain, front view.
PDB entry 1ijx coloured by chain, side view.
PDB entry 1ijx coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.
Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ
Nature 412 86-90 (2001)
PMID: 11452312

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161300 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Secreted frizzled-related protein 3 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 127 amino acids
Theoretical weight: 14.2 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P97401 (Residues: 33-157; Coverage: 43%)
Gene names: Fiz, Fre, Frzb, Frzb1, Sfrp3
Sequence domains: Fz domain
Structure domains: Frizzled cysteine-rich domain

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 96.05Å b: 48.69Å c: 83.31Å
α: 90° β: 90.8° γ: 90°
R-values:
R R work R free
0.22 0.22 0.257
Expression system: Cricetulus griseus

Quick links

Citations

90 review citations

The Wnt signaling pathway in development and disease.
Logan et al. (2004)
89 more

13 mentions without citation

The structural biology of canonical Wnt signalling.
Agostino et al. (2020)
12 more