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Crystal structure of the transthyretin mutant TTR C10A/Y114C

X-ray diffraction
1.7Å resolution
PDB entry 1ijn coloured by chain, front view.
PDB entry 1ijn coloured by chain, side view.
PDB entry 1ijn coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
homo tetramer
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Transthyretin
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Multimeric state: homo tetramer
Accessible surface area: 19120.94 Å2
Buried surface area: 9208.96 Å2
Dissociation area: 461.93 Å2
Dissociation energy (ΔGdiss): 3.4 kcal/mol
Dissociation entropy (TΔSdiss): 3.49 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-136168
Assembly 2 (preferred)
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Assembly Name: Transthyretin
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Multimeric state: homo dimer
Accessible surface area: 10932.11 Å2
Buried surface area: 3240.36 Å2
Dissociation area: 998.36 Å2
Dissociation energy (ΔGdiss): 3.6 kcal/mol
Dissociation entropy (TΔSdiss): 11.57 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136167

Macromolecules

Transthyretin
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Pfam: HIUase/Transthyretin family
InterPro:
CATH: Transthyretin/hydroxyisourate hydrolase domain
SCOP: Transthyretin (synonym: prealbumin)
Transthyretin in PDB entry 1ijn, assembly 2, front view.
Transthyretin in PDB entry 1ijn, assembly 2, side view.
Transthyretin in PDB entry 1ijn, assembly 2, top view.
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