PDBe 1igz

X-ray diffraction
2.9Å resolution

Crystal Structure of Linoleic acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.


Function and Biology Details

Reaction catalysed:
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Prostaglandin G/H synthase 1 Chain: A
Molecule details ›
Chain: A
Length: 576 amino acids
Theoretical weight: 66.16 KDa
Source organism: Ovis aries
  • Canonical: P05979 (Residues: 25-600; Coverage: 100%)
Gene names: COX1, PTGS1
Sequence domains:
Structure domains:

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6522
Unit cell:
a: 182.05Å b: 182.05Å c: 103.65Å
α: 90° β: 90° γ: 120°
R R work R free
0.234 0.234 0.27