PDBe 1igr

X-ray diffraction
2.6Å resolution

Type 1 Insulin-like growth factor receptor (DOMAINS 1-3)


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Insulin-like growth factor 1 receptor alpha chain Chain: A
Molecule details ›
Chain: A
Length: 478 amino acids
Theoretical weight: 54.39 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
  • Canonical: P08069 (Residues: 31-492; Coverage: 35%)
Gene name: IGF1R
Sequence domains:
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE M18XHF
Spacegroup: P212121
Unit cell:
a: 77.39Å b: 99.72Å c: 120.29Å
α: 90° β: 90° γ: 90°
R R work R free
0.237 0.237 0.304
Expression system: Cricetulus griseus