PDBe 1ias

X-ray diffraction
2.9Å resolution

CYTOPLASMIC DOMAIN OF UNPHOSPHORYLATED TYPE I TGF-BETA RECEPTOR CRYSTALLIZED WITHOUT FKBP12

Released:

Function and Biology Details

Reaction catalysed:
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TGF-beta receptor type-1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 342 amino acids
Theoretical weight: 38.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P36897 (Residues: 162-503; Coverage: 73%)
Gene names: ALK5, SKR4, TGFBR1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: C2221
Unit cell:
a: 172.56Å b: 251.617Å c: 140.228Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.255 0.255 0.284
Expression system: Spodoptera frugiperda