Function and Biology

CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (ADP-MG COMPLEX)

Source organism: Mus musculus
Biochemical function: ATP binding
Biological process: protein phosphorylation
Cellular component: not assigned

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02816
Domain description: Alpha-kinase family
Occurring in:
  1. Transient receptor potential cation channel subfamily M member 7
The deposited structure of PDB entry 1iah contains 2 copies of Pfam domain PF02816 (Alpha-kinase family) in Transient receptor potential cation channel subfamily M member 7. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR004166
Domain description: Alpha-type protein kinase, alpha-kinase domain
Occurring in:
  1. Transient receptor potential cation channel subfamily M member 7
IPR029601
Domain description: Transient receptor potential cation channel subfamily M member 7, alpha-kinase domain
Occurring in:
  1. Transient receptor potential cation channel subfamily M member 7
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Transient receptor potential cation channel subfamily M member 7

Structure domains

CATH CATH domains
3.20.200.10
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: Protein kinase-like fold
Homology: MHCK/EF2 kinase
Occurring in:
  1. Transient receptor potential cation channel subfamily M member 7
The deposited structure of PDB entry 1iah contains 2 copies of CATH domain 3.20.200.10 (Protein kinase-like fold) in Transient receptor potential cation channel subfamily M member 7. Showing 1 copy in chain B.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Transient receptor potential cation channel subfamily M member 7
The deposited structure of PDB entry 1iah contains 2 copies of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Transient receptor potential cation channel subfamily M member 7. Showing 1 copy in chain B.
SCOP SCOP annotation
64408
Class: Alpha and beta proteins (a+b)
Fold: Protein kinase-like (PK-like)
Superfamily: Protein kinase-like (PK-like)
Occurring in:
  1. Transient receptor potential cation channel subfamily M member 7
The deposited structure of PDB entry 1iah contains 2 copies of SCOP domain 64408 (MHCK/EF2 kinase) in Transient receptor potential cation channel subfamily M member 7. Showing 1 copy in chain B.