PDBe 1i7i

X-ray diffraction
2.35Å resolution

CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IN COMPLEX WITH THE AGONIST AZ 242

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 292 amino acids
Theoretical weight: 33.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Best match: P37231 (Residues: 225-505)
Gene names: NR1C3, PPARG

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: C2
Unit cell:
a: 92.928Å b: 61.781Å c: 118.981Å
α: 90° β: 101.52° γ: 90°
R-values:
R R work R free
0.238 0.238 0.284
Expression system: Escherichia coli