› › Function and Biology

RNA POLYMERASE II ELONGATION COMPLEX

Source organism: Saccharomyces cerevisiae
Biochemical function: RNA-dependent RNA polymerase activity
Biological process: transcription elongation by RNA polymerase II
Cellular component: RNA polymerase II, core complex

Quick links

EC 2.7.7.6: DNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • C RNA formation factors
  • C ribonucleic acid formation factors
  • DNA-dependent RNA nucleotidyltransferase
  • DNA-dependent RNA polymerase
  • DNA-dependent ribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid-dependent ribonucleic acid polymerase
  • RNA nucleotidyltransferase
  • RNA nucleotidyltransferase (DNA-directed)
  • RNA polymerase
  • RNA polymerase I
  • RNA polymerase II
  • RNA polymerase III
  • RNA transcriptase
  • Ribonucleate nucleotidyltransferase
  • Ribonucleate polymerase
  • Ribonucleic acid nucleotidyltransferase
  • Ribonucleic acid polymerase
  • Ribonucleic acid transcriptase
  • Ribonucleic polymerase
  • Ribonucleic transcriptase
  • Transcriptase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF05001
Domain description: RNA polymerase Rpb1 C-terminal repeat
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 1i6h contains 12 copies of Pfam domain PF05001 (RNA polymerase Rpb1 C-terminal repeat) in DNA-directed RNA polymerase II subunit RPB1. Showing 12 copies in chain C [auth A] (this domain is out of the observed residue ranges!).

PF01193
Domain description: RNA polymerase Rpb3/Rpb11 dimerisation domain
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
  2. DNA-directed RNA polymerase II subunit RPB11
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF01193 (RNA polymerase Rpb3/Rpb11 dimerisation domain) in DNA-directed RNA polymerase II subunit RPB3. Showing 1 copy in chain E [auth C].

PF03604
Domain description: DNA directed RNA polymerase, 7 kDa subunit
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC4
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF03604 (DNA directed RNA polymerase, 7 kDa subunit) in DNA-directed RNA polymerases I, II, and III subunit RPABC4. Showing 1 copy in chain L.

PF13656
Domain description: RNA polymerase Rpb3/Rpb11 dimerisation domain
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB11
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF13656 (RNA polymerase Rpb3/Rpb11 dimerisation domain) in DNA-directed RNA polymerase II subunit RPB11. Showing 1 copy in chain K.

PF01194
Domain description: RNA polymerases N / 8 kDa subunit
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC5
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF01194 (RNA polymerases N / 8 kDa subunit) in DNA-directed RNA polymerases I, II, and III subunit RPABC5. Showing 1 copy in chain J.

PF01096
Domain description: Transcription factor S-II (TFIIS)
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB9
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF01096 (Transcription factor S-II (TFIIS)) in DNA-directed RNA polymerase II subunit RPB9. Showing 1 copy in chain I.

PF02150
Domain description: RNA polymerases M/15 Kd subunit
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB9
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF02150 (RNA polymerases M/15 Kd subunit) in DNA-directed RNA polymerase II subunit RPB9. Showing 1 copy in chain I.

PF03870
Domain description: RNA polymerase Rpb8
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC3
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF03870 (RNA polymerase Rpb8) in DNA-directed RNA polymerases I, II, and III subunit RPABC3. Showing 1 copy in chain H.

PF01192
Domain description: RNA polymerase Rpb6
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF01192 (RNA polymerase Rpb6) in DNA-directed RNA polymerases I, II, and III subunit RPABC2. Showing 1 copy in chain G [auth F].

PF01191
Domain description: RNA polymerase Rpb5, C-terminal domain
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF01191 (RNA polymerase Rpb5, C-terminal domain) in DNA-directed RNA polymerases I, II, and III subunit RPABC1. Showing 1 copy in chain F [auth E].

PF03871
Domain description: RNA polymerase Rpb5, N-terminal domain
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF03871 (RNA polymerase Rpb5, N-terminal domain) in DNA-directed RNA polymerases I, II, and III subunit RPABC1. Showing 1 copy in chain F [auth E].

PF01000
Domain description: RNA polymerase Rpb3/RpoA insert domain
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF01000 (RNA polymerase Rpb3/RpoA insert domain) in DNA-directed RNA polymerase II subunit RPB3. Showing 1 copy in chain E [auth C].

PF04560
Domain description: RNA polymerase Rpb2, domain 7
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF04560 (RNA polymerase Rpb2, domain 7) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain D [auth B].

PF00562
Domain description: RNA polymerase Rpb2, domain 6
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF00562 (RNA polymerase Rpb2, domain 6) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain D [auth B].

PF04567
Domain description: RNA polymerase Rpb2, domain 5
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF04567 (RNA polymerase Rpb2, domain 5) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain D [auth B].

PF04566
Domain description: RNA polymerase Rpb2, domain 4
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF04566 (RNA polymerase Rpb2, domain 4) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain D [auth B].

PF04565
Domain description: RNA polymerase Rpb2, domain 3
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF04565 (RNA polymerase Rpb2, domain 3) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain D [auth B].

PF04561
Domain description: RNA polymerase Rpb2, domain 2
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF04561 (RNA polymerase Rpb2, domain 2) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain D [auth B].

PF04563
Domain description: RNA polymerase beta subunit
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF04563 (RNA polymerase beta subunit) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain D [auth B].

PF04990
Domain description: RNA polymerase Rpb1, domain 7
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF04990 (RNA polymerase Rpb1, domain 7) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain C [auth A].

PF04992
Domain description: RNA polymerase Rpb1, domain 6
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF04992 (RNA polymerase Rpb1, domain 6) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain C [auth A].

PF04998
Domain description: RNA polymerase Rpb1, domain 5
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF04998 (RNA polymerase Rpb1, domain 5) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain C [auth A].

PF05000
Domain description: RNA polymerase Rpb1, domain 4
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF05000 (RNA polymerase Rpb1, domain 4) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain C [auth A].

PF04983
Domain description: RNA polymerase Rpb1, domain 3
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF04983 (RNA polymerase Rpb1, domain 3) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain C [auth A].

PF00623
Domain description: RNA polymerase Rpb1, domain 2
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF00623 (RNA polymerase Rpb1, domain 2) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain C [auth A].

PF04997
Domain description: RNA polymerase Rpb1, domain 1
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 1i6h contains 1 copy of Pfam domain PF04997 (RNA polymerase Rpb1, domain 1) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain C [auth A].

InterPro InterPro annotations
IPR000684
Domain description: RNA polymerase II, heptapeptide repeat, eukaryotic
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR000268
Domain description: DNA-directed RNA polymerase subunit RPABC5/Rpb10
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC5
IPR001222
Domain description: Zinc finger, TFIIS-type
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB9
IPR036603
Domain description: RNA polymerase, RBP11-like subunit
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
  2. DNA-directed RNA polymerase II subunit RPB11
IPR005570
Domain description: DNA-directed RNA polymerases I, II, and III subunit RPABC3
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC3
IPR014381
Domain description: DNA-directed RNA polymerase subunit Rpo5/Rpb5
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR006591
Domain description: RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC4
IPR001529
Domain description: DNA-directed RNA polymerase, M/15kDa subunit
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB9
IPR012164
Domain description: DNA-directed RNA polymerase subunit/transcription factor S
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB9
IPR012340
Domain description: Nucleic acid-binding, OB-fold
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC3
IPR006110
Domain description: RNA polymerase, subunit omega/Rpo6/RPB6
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
IPR036161
Domain description: RPB6/omega subunit-like superfamily
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
IPR006111
Domain description: Archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
IPR036710
Domain description: RNA polymerase Rpb5, N-terminal domain superfamily
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR036643
Domain description: DNA-directed RNA polymerase, insert domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
IPR011263
Domain description: DNA-directed RNA polymerase, RpoA/D/Rpb3-type
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
IPR015712
Domain description: DNA-directed RNA polymerase, subunit 2
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR044893
Domain description: RNA polymerase Rpb1, clamp domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR029040
Domain description: RNA polymerase subunit RPABC4/transcription elongation factor Spt4
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC4
IPR039747
Domain description: DNA-directed RNA polymerases I, II, and III subunit RPABC4
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC4
IPR008193
Domain description: DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB11
IPR009025
Domain description: DNA-directed RNA polymerase, RBP11-like dimerisation domain
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB11
IPR022905
Domain description: DNA-directed RNA polymerase subunit Rpo11-like
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB11
IPR037685
Domain description: RNA polymerase RBP11
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB11
IPR020789
Domain description: RNA polymerases, subunit N, zinc binding site
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC5
IPR023580
Domain description: RNA polymerase subunit RPB10
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC5
IPR034012
Domain description: Pol II subunit B9, C-terminal zinc ribbon
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB9
IPR019761
Domain description: DNA-directed RNA polymerase M, 15kDa subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB9
IPR020708
Domain description: DNA-directed RNA polymerase, 14-18kDa subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
IPR028363
Domain description: DNA-directed RNA polymerase, subunit RPB6
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
IPR020608
Domain description: RNA polymerase, subunit H/Rpb5, conserved site
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR000783
Domain description: RNA polymerase, subunit H/Rpb5 C-terminal
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR035913
Domain description: RPB5-like RNA polymerase subunit superfamily
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR005571
Domain description: RNA polymerase, Rpb5, N-terminal
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR011262
Domain description: DNA-directed RNA polymerase, insert domain
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
IPR001514
Domain description: DNA-directed RNA polymerase, 30-40kDa subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
IPR022842
Domain description: DNA-directed RNA polymerase subunit Rpo3/Rpb3/RPAC1
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
IPR007641
Domain description: RNA polymerase Rpb2, domain 7
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR007121
Domain description: RNA polymerase, beta subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR014724
Domain description: RNA polymerase Rpb2, OB-fold
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR037033
Domain description: DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR007120
Domain description: DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR007647
Domain description: RNA polymerase Rpb2, domain 5
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR007646
Domain description: RNA polymerase Rpb2, domain 4
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR007645
Domain description: RNA polymerase Rpb2, domain 3
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR037034
Domain description: RNA polymerase Rpb2, domain 2 superfamily
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR007642
Domain description: RNA polymerase Rpb2, domain 2
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR007644
Domain description: RNA polymerase, beta subunit, protrusion
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR038593
Domain description: RNA polymerase Rpb1, domain 7 superfamily
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR007073
Domain description: RNA polymerase Rpb1, domain 7
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR007075
Domain description: RNA polymerase Rpb1, domain 6
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR007081
Domain description: RNA polymerase Rpb1, domain 5
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR007083
Domain description: RNA polymerase Rpb1, domain 4
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR038120
Domain description: RNA polymerase Rpb1, funnel domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR042102
Domain description: RNA polymerase Rpb1, domain 3 superfamily
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR007066
Domain description: RNA polymerase Rpb1, domain 3
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR000722
Domain description: RNA polymerase, alpha subunit
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR006592
Domain description: RNA polymerase, N-terminal
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR045867
Domain description: DNA-directed RNA polymerase, subunit beta-prime
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR007080
Domain description: RNA polymerase Rpb1, domain 1
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1

Structure domains

CATH CATH domains
3.30.1360.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Gyrase A; domain 2
Homology: RNA polymerase, RBP11-like subunit
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
  2. DNA-directed RNA polymerase II subunit RPB11
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 3.30.1360.10 (Gyrase A; domain 2) in DNA-directed RNA polymerase II subunit RPB3. Showing 1 copy in chain E [auth C].
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 3.30.1360.10 (Gyrase A; domain 2) in DNA-directed RNA polymerase II subunit RPB11. Showing 1 copy in chain K.
2.40.270.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6
Homology: DNA-directed RNA polymerase, subunit 2, domain 6
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 2.40.270.10 (Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain D [auth B].
2.20.25.10
Class: Mainly Beta
Architecture: Single Sheet
Topology: N-terminal domain of TfIIb
Homology: N-terminal domain of TfIIb
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB9
The deposited structure of PDB entry 1i6h contains 2 copies of CATH domain 2.20.25.10 (N-terminal domain of TfIIb) in DNA-directed RNA polymerase II subunit RPB9. Showing 2 copies in chain I.
2.40.50.150
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 2.40.50.150 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain D [auth B].
2.40.40.20
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Barwin-like endoglucanases
Homology: Barwin-like endoglucanases
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 2.40.40.20 (Barwin-like endoglucanases) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain C [auth A].
2.20.28.30
Class: Mainly Beta
Architecture: Single Sheet
Topology: Rubrerythrin, domain 2
Homology: RNA polymerase ii, chain L
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC4
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 2.20.28.30 (Rubrerythrin, domain 2) in DNA-directed RNA polymerases I, II, and III subunit RPABC4. Showing 1 copy in chain L.
1.10.10.60
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Homeodomain-like
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC5
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 1.10.10.60 (Arc Repressor Mutant, subunit A) in DNA-directed RNA polymerases I, II, and III subunit RPABC5. Showing 1 copy in chain J.
2.40.50.140
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: Nucleic acid-binding proteins
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC3
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 2.40.50.140 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in DNA-directed RNA polymerases I, II, and III subunit RPABC3. Showing 1 copy in chain H.
3.90.940.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Eukaryotic RPB6 RNA polymerase subunit
Homology: Eukaryotic RPB6 RNA polymerase subunit
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 3.90.940.10 (Eukaryotic RPB6 RNA polymerase subunit) in DNA-directed RNA polymerases I, II, and III subunit RPABC2. Showing 1 copy in chain G [auth F].
3.90.940.20
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Eukaryotic RPB6 RNA polymerase subunit
Homology: RPB5-like RNA polymerase subunit
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 3.90.940.20 (Eukaryotic RPB6 RNA polymerase subunit) in DNA-directed RNA polymerases I, II, and III subunit RPABC1. Showing 1 copy in chain F [auth E].
3.40.1340.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1
Homology: RNA polymerase, Rpb5, N-terminal domain
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 3.40.1340.10 (Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1) in DNA-directed RNA polymerases I, II, and III subunit RPABC1. Showing 1 copy in chain F [auth E].
2.170.120.12
Class: Mainly Beta
Architecture: Beta Complex
Topology: RNA Polymerase Alpha Subunit; Chain A, domain 2
Homology: DNA-directed RNA polymerase, insert domain
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 2.170.120.12 (RNA Polymerase Alpha Subunit; Chain A, domain 2) in DNA-directed RNA polymerase II subunit RPB3. Showing 1 copy in chain E [auth C].
3.90.1800.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: DCoH-like
Homology: RNA polymerase alpha subunit dimerisation domain
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 3.90.1800.10 (DCoH-like) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain D [auth B].
3.90.1070.20
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Hypothetical Protein Ta0175; Chain: A, domain 2
Homology: Hypothetical Protein Ta0175; Chain: A, domain 2
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 3.90.1070.20 (Hypothetical Protein Ta0175; Chain: A, domain 2) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain D [auth B].
3.90.1110.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3
Homology: RNA polymerase Rpb2, domain 2
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 3.90.1110.10 (Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain D [auth B].
3.30.1360.140
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Gyrase A; domain 2
Homology: Gyrase A; domain 2
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 3.30.1360.140 (Gyrase A; domain 2) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain C [auth A].
1.10.132.30
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Topoisomerase I; Chain A, domain 4
Homology: Topoisomerase I; Chain A, domain 4
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 1.10.132.30 (Topoisomerase I; Chain A, domain 4) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain C [auth A].
1.10.274.100
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Enzyme I; Chain A, domain 2
Homology: RNA polymerase Rpb1, domain 3
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 1.10.274.100 (Enzyme I; Chain A, domain 2) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain C [auth A].
3.30.1490.180
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Dna Ligase; domain 1
Homology: RNA polymerase ii
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 1i6h contains 1 copy of CATH domain 3.30.1490.180 (Dna Ligase; domain 1) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain C [auth A].
SCOP SCOP annotations
57784
Class: Small proteins
Fold: Rubredoxin-like
Superfamily: Zinc beta-ribbon
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB9
The deposited structure of PDB entry 1i6h contains 2 copies of SCOP domain 57784 (Transcriptional factor domain) in DNA-directed RNA polymerase II subunit RPB9. Showing 2 copies in chain I.
55258
Class: Alpha and beta proteins (a+b)
Fold: DCoH-like
Superfamily: RBP11-like subunits of RNA polymerase
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
The deposited structure of PDB entry 1i6h contains 1 copy of SCOP domain 55258 (RNA polymerase alpha subunit dimerisation domain) in DNA-directed RNA polymerase II subunit RPB3. Showing 1 copy in chain E [auth C].
64576
Class: Small proteins
Fold: Rubredoxin-like
Superfamily: RNA polymerase subunits
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC4
The deposited structure of PDB entry 1i6h contains 1 copy of SCOP domain 64576 (RBP12 subunit of RNA polymerase II) in DNA-directed RNA polymerases I, II, and III subunit RPABC4. Showing 1 copy in chain L.
64311
Class: Alpha and beta proteins (a+b)
Fold: DCoH-like
Superfamily: RBP11-like subunits of RNA polymerase
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB11
The deposited structure of PDB entry 1i6h contains 1 copy of SCOP domain 64311 (RBP11/RpoL) in DNA-directed RNA polymerase II subunit RPB11. Showing 1 copy in chain K.
46925
Class: All alpha proteins
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: RNA polymerase subunit RPB10
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC5
The deposited structure of PDB entry 1i6h contains 1 copy of SCOP domain 46925 (RNA polymerase subunit RPB10) in DNA-directed RNA polymerases I, II, and III subunit RPABC5. Showing 1 copy in chain J.
50321
Class: All beta proteins
Fold: OB-fold
Superfamily: Nucleic acid-binding proteins
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC3
The deposited structure of PDB entry 1i6h contains 1 copy of SCOP domain 50321 (RNA polymerase subunit RBP8) in DNA-directed RNA polymerases I, II, and III subunit RPABC3. Showing 1 copy in chain H.
55294
Class: All alpha proteins
Fold: RPB6/omega subunit-like
Superfamily: RPB6/omega subunit-like
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
The deposited structure of PDB entry 1i6h contains 1 copy of SCOP domain 55294 (RPB6) in DNA-directed RNA polymerases I, II, and III subunit RPABC2. Showing 1 copy in chain G [auth F].
55288
Class: Alpha and beta proteins (a+b)
Fold: RPB5-like RNA polymerase subunit
Superfamily: RPB5-like RNA polymerase subunit
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
The deposited structure of PDB entry 1i6h contains 1 copy of SCOP domain 55288 (RPB5) in DNA-directed RNA polymerases I, II, and III subunit RPABC1. Showing 1 copy in chain F [auth E].
53037
Class: Alpha and beta proteins (a/b)
Fold: Restriction endonuclease-like
Superfamily: Eukaryotic RPB5 N-terminal domain
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
The deposited structure of PDB entry 1i6h contains 1 copy of SCOP domain 53037 (Eukaryotic RPB5 N-terminal domain) in DNA-directed RNA polymerases I, II, and III subunit RPABC1. Showing 1 copy in chain F [auth E].
56554
Class: Alpha and beta proteins (a+b)
Fold: Insert subdomain of RNA polymerase alpha subunit
Superfamily: Insert subdomain of RNA polymerase alpha subunit
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
The deposited structure of PDB entry 1i6h contains 1 copy of SCOP domain 56554 (Insert subdomain of RNA polymerase alpha subunit) in DNA-directed RNA polymerase II subunit RPB3. Showing 1 copy in chain E [auth C].
64485
Class: Multi-domain proteins (alpha and beta)
Fold: beta and beta-prime subunits of DNA dependent RNA-polymerase
Superfamily: beta and beta-prime subunits of DNA dependent RNA-polymerase
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 1i6h contains 1 copy of SCOP domain 64485 (RNA-polymerase beta) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain D [auth B].
64490
Class: Multi-domain proteins (alpha and beta)
Fold: beta and beta-prime subunits of DNA dependent RNA-polymerase
Superfamily: beta and beta-prime subunits of DNA dependent RNA-polymerase
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 1i6h contains 1 copy of SCOP domain 64490 (RNA-polymerase beta-prime) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain C [auth A].

Quick links