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Crystal structure of recombinant human interleukin-1 beta at 2.0 A resolution.

Finzel BC, Clancy LL, Holland DR, Muchmore SW, Watenpaugh KD, Einspahr HM
J Mol Biol 209 779-91 (1989)
Cited: 116 times
EuropePMC logo PMID: 2585509

Abstract

The crystal structure of recombinant human interleukin-1 beta (IL-1 beta) has been determined at 2.0 A resolution and refined to a crystallographic R-factor of 0.19. Three heavy-atom derivatives were identified and used for multiple isomorphous replacement phasing. Interpretation of the resulting electron density map revealed a structure in which there are 12 antiparallel beta-strands and no alpha-helix. The single 153-residue polypeptide chain is folded into a six-stranded beta-barrel similar in architecture to the Kunitz-type trypsin inhibitor found in soybeans. The molecule displays approximate 3-fold symmetry about the axis of the beta-barrel. Each successive pair of component strands of the barrel brackets an extensive sequence outside the barrel that includes an additional pair of beta-strands and a prominent loop. Together, these three external segments conceal much of the perimeter and one end of the barrel, leaving only the end supporting the chain termini fully exposed. The structure can be used to identify portions of the polypeptide chain that are exposed on the surface of the molecule, some of which must be epitopes recognized by interleukin-1 beta receptors.

Reviews - 1i1b mentioned but not cited (2)

  1. Structural biology of the IL-1 superfamily: key cytokines in the regulation of immune and inflammatory responses. Krumm B, Xiang Y, Deng J. Protein Sci 23 526-538 (2014)
  2. Peptidoglycan O-Acetylation as a Virulence Factor: Its Effect on Lysozyme in the Innate Immune System. Brott AS, Clarke AJ. Antibiotics (Basel) 8 E94 (2019)

Articles - 1i1b mentioned but not cited (12)

  1. High throughput protein fold identification by using experimental constraints derived from intramolecular cross-links and mass spectrometry. Young MM, Tang N, Hempel JC, Oshiro CM, Taylor EW, Kuntz ID, Gibson BW, Dollinger G. Proc Natl Acad Sci U S A 97 5802-5806 (2000)
  2. NMR structure determination for larger proteins using backbone-only data. Raman S, Lange OF, Rossi P, Tyka M, Wang X, Aramini J, Liu G, Ramelot TA, Eletsky A, Szyperski T, Kennedy MA, Prestegard J, Montelione GT, Baker D. Science 327 1014-1018 (2010)
  3. Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor. Goetz R, Ohnishi M, Kir S, Kurosu H, Wang L, Pastor J, Ma J, Gai W, Kuro-o M, Razzaque MS, Mohammadi M. J Biol Chem 287 29134-29146 (2012)
  4. Structure, evolutionary conservation, and conformational dynamics of Homo sapiens fascin-1, an F-actin crosslinking protein. Sedeh RS, Fedorov AA, Fedorov EV, Ono S, Matsumura F, Almo SC, Bathe M. J Mol Biol 400 589-604 (2010)
  5. Systematic comparison of crystal and NMR protein structures deposited in the protein data bank. Sikic K, Tomic S, Carugo O. Open Biochem J 4 83-95 (2010)
  6. Screened nonbonded interactions in native proteins manipulate optimal paths for robust residue communication. Atilgan AR, Turgut D, Atilgan C. Biophys J 92 3052-3062 (2007)
  7. Integrated bioinformatics and network pharmacology to identify the therapeutic target and molecular mechanisms of Huangqin decoction on ulcerative Colitis. Wu Y, Liu X, Li G. Sci Rep 12 159 (2022)
  8. Predicting protein folding cores by empirical potential functions. Chen M, Dousis AD, Wu Y, Wittung-Stafshede P, Ma J. Arch Biochem Biophys 483 16-22 (2009)
  9. The response of Greek key proteins to changes in connectivity depends on the nature of their secondary structure. Kemplen KR, De Sancho D, Clarke J. J Mol Biol 427 2159-2165 (2015)
  10. Network pharmacology and molecular docking-based investigation on traditional Chinese medicine Astragalus membranaceus in oral ulcer treatment. Zhong W, Tao SY, Guo X, Cheng XF, Yuan Q, Li CX, Tian HY, Yang S, Sunchuri D, Guo ZL. Medicine (Baltimore) 102 e34744 (2023)
  11. Network pharmacology identifies the inhibitory effect of Yiqiyangyinquyu prescription on salivary gland inflammation in Sjögren's syndrome. Hong T, Chen W, Ren YT, Wang YH, Lu DQ, Zhang KY, Yao XY, Wang XC. Medicine (Baltimore) 102 e36144 (2023)
  12. Potential Targets and Mechanisms of Bitter Almond-Licorice for COVID-19 Treatment Based on Network Pharmacology and Molecular Docking. Hong Q, Shang X, Wu Y, Nie Z, He B. Curr Pharm Des 29 2655-2667 (2023)


Reviews citing this publication (19)

  1. Mutations and off-pathway aggregation of proteins. Wetzel R. Trends Biotechnol 12 193-198 (1994)
  2. Considering protonation as a posttranslational modification regulating protein structure and function. Schönichen A, Webb BA, Jacobson MP, Barber DL. Annu Rev Biophys 42 289-314 (2013)
  3. A Mechanistic Understanding of Pyroptosis: The Fiery Death Triggered by Invasive Infection. Liu X, Lieberman J. Adv Immunol 135 81-117 (2017)
  4. Protein folds in the all-beta and all-alpha classes. Chothia C, Hubbard T, Brenner S, Barns H, Murzin A. Annu Rev Biophys Biomol Struct 26 597-627 (1997)
  5. Interleukin 1 signal transduction--current concepts and relevance to periodontitis. Boch JA, Wara-aswapati N, Auron PE. J Dent Res 80 400-407 (2001)
  6. Functional implications of interleukin-1 beta based on the three-dimensional structure. Veerapandian B, Gilliland GL, Raag R, Svensson AL, Masui Y, Hirai Y, Poulos TL. Proteins 12 10-23 (1992)
  7. Comparison of protein structures determined by NMR in solution and by X-ray diffraction in single crystals. Billeter M. Q Rev Biophys 25 325-377 (1992)
  8. Structural, functional and evolutionary implications of the three-dimensional crystal structure of murine interferon-beta. Mitsui Y, Senda T, Shimazu T, Matsuda S, Utsumi J. Pharmacol Ther 58 93-132 (1993)
  9. Young Investigator Award Lecture. Structures of larger proteins, protein-ligand and protein-DNA complexes by multidimensional heteronuclear NMR. Clore GM, Gronenborn AM. Protein Sci 3 372-390 (1994)
  10. Structure of coiled beta-beta-hairpins and beta-beta-corners. Efimov AV. FEBS Lett 284 288-292 (1991)
  11. A review about nothing: are apolar cavities in proteins really empty? Matthews BW, Liu L. Protein Sci 18 494-502 (2009)
  12. Cytokines: from clone to clinic. Aggarwal BB, Pocsik E. Arch Biochem Biophys 292 335-359 (1992)
  13. Common structural motifs in small proteins and domains. Efimov AV. FEBS Lett 355 213-219 (1994)
  14. Omnipresence of inflammasome activities in inflammatory bone diseases. Alippe Y, Mbalaviele G. Semin Immunopathol 41 607-618 (2019)
  15. Chemical neuroimmunology: health in a nutshell bidirectional communication between immune and stress (limbic-hypothalamic-pituitary-adrenal) systems. Lozovaya N, Miller AD. Chembiochem 4 466-484 (2003)
  16. Structures of larger proteins, protein-ligand and protein-DNA complexes by multi-dimensional heteronuclear NMR. Clore GM, Gronenborn AM. Prog Biophys Mol Biol 62 153-184 (1994)
  17. Protein targets for structure-based drug design. Walkinshaw MD. Med Res Rev 12 317-372 (1992)
  18. Interferons alpha/beta and their receptors: place in the hierarchy of cytokines. Zav'Yalov VP, Zav'Yalova GA. APMIS 105 161-186 (1997)
  19. Functional and structural characteristics of bacterial proteins that bind host cytokines. Högbom M, Ihalin R. Virulence 8 1592-1601 (2017)

Articles citing this publication (83)

  1. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J. Nature 535 153-158 (2016)
  2. Accurate modeling of protein conformation by automatic segment matching. Levitt M. J Mol Biol 226 507-533 (1992)
  3. beta-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors. Murzin AG, Lesk AM, Chothia C. J Mol Biol 223 531-543 (1992)
  4. Hydrophilicity of cavities in proteins. Zhang L, Hermans J. Proteins 24 433-438 (1996)
  5. Three-dimensional structure of human basic fibroblast growth factor. Eriksson AE, Cousens LS, Weaver LH, Matthews BW. Proc Natl Acad Sci U S A 88 3441-3445 (1991)
  6. Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism. Eisenberg SP, Brewer MT, Verderber E, Heimdal P, Brandhuber BJ, Thompson RC. Proc Natl Acad Sci U S A 88 5232-5236 (1991)
  7. Kunitz-type soybean trypsin inhibitor revisited: refined structure of its complex with porcine trypsin reveals an insight into the interaction between a homologous inhibitor from Erythrina caffra and tissue-type plasminogen activator. Song HK, Suh SW. J Mol Biol 275 347-363 (1998)
  8. Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta. Zhang JD, Cousens LS, Barr PJ, Sprang SR. Proc Natl Acad Sci U S A 88 3446-3450 (1991)
  9. A 500 ps molecular dynamics simulation study of interleukin-1 beta in water. Correlation with nuclear magnetic resonance spectroscopy and crystallography. Chandrasekhar I, Clore GM, Szabo A, Gronenborn AM, Brooks BR. J Mol Biol 226 239-250 (1992)
  10. Principles determining the structure of beta-sheet barrels in proteins. II. The observed structures. Murzin AG, Lesk AM, Chothia C. J Mol Biol 236 1382-1400 (1994)
  11. Three-dimensional crystal structure of recombinant murine interferon-beta. Senda T, Shimazu T, Matsuda S, Kawano G, Shimizu H, Nakamura KT, Mitsui Y. EMBO J 11 3193-3201 (1992)
  12. Analysis of proton chemical shifts in regular secondary structure of proteins. Osapay K, Case DA. J Biomol NMR 4 215-230 (1994)
  13. Deviations from planarity of the peptide bond in peptides and proteins. MacArthur MW, Thornton JM. J Mol Biol 264 1180-1195 (1996)
  14. Crystal structure of a Kunitz-type trypsin inhibitor from Erythrina caffra seeds. Onesti S, Brick P, Blow DM. J Mol Biol 217 153-176 (1991)
  15. Crystal structure of the cysteine-rich domain of mannose receptor complexed with a sulfated carbohydrate ligand. Liu Y, Chirino AJ, Misulovin Z, Leteux C, Feizi T, Nussenzweig MC, Bjorkman PJ. J Exp Med 191 1105-1116 (2000)
  16. Correlation between 15N NMR chemical shifts in proteins and secondary structure. Le H, Oldfield E. J Biomol NMR 4 341-348 (1994)
  17. High-level secretion of correctly processed recombinant human interleukin-1 beta in Kluyveromyces lactis. Fleer R, Chen XJ, Amellal N, Yeh P, Fournier A, Guinet F, Gault N, Faucher D, Folliard F, Fukuhara H. Gene 107 285-295 (1991)
  18. A simple atomic-level hydrophobicity scale reveals protein interfacial structure. Kapcha LH, Rossky PJ. J Mol Biol 426 484-498 (2014)
  19. Correlation of observed fold frequency with the occurrence of local structural motifs. Salem GM, Hutchinson EG, Orengo CA, Thornton JM. J Mol Biol 287 969-981 (1999)
  20. ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages. Zha QB, Wei HX, Li CG, Liang YD, Xu LH, Bai WJ, Pan H, He XH, Ouyang DY. Front Immunol 7 597 (2016)
  21. Refined crystal structure of the interleukin-1 receptor antagonist. Presence of a disulfide link and a cis-proline. Schreuder HA, Rondeau JM, Tardif C, Soffientini A, Sarubbi E, Akeson A, Bowlin TL, Yanofsky S, Barrett RW. Eur J Biochem 227 838-847 (1995)
  22. Structure of hisactophilin is similar to interleukin-1 beta and fibroblast growth factor. Habazettl J, Gondol D, Wiltscheck R, Otlewski J, Schleicher M, Holak TA. Nature 359 855-858 (1992)
  23. Conversion of the interleukin 1 receptor antagonist into an agonist by site-specific mutagenesis. Ju G, Labriola-Tompkins E, Campen CA, Benjamin WR, Karas J, Plocinski J, Biondi D, Kaffka KL, Kilian PL, Eisenberg SP. Proc Natl Acad Sci U S A 88 2658-2662 (1991)
  24. Identification of the discontinuous binding site in human interleukin 1 beta for the type I interleukin 1 receptor. Labriola-Tompkins E, Chandran C, Kaffka KL, Biondi D, Graves BJ, Hatada M, Madison VS, Karas J, Kilian PL, Ju G. Proc Natl Acad Sci U S A 88 11182-11186 (1991)
  25. Letter Structure of benzyl T-antigen disaccharide bound to Amaranthus caudatus agglutinin. Transue TR, Smith AK, Mo H, Goldstein IJ, Saper MA. Nat Struct Biol 4 779-783 (1997)
  26. Refinement of the structure of human basic fibroblast growth factor at 1.6 A resolution and analysis of presumed heparin binding sites by selenate substitution. Eriksson AE, Cousens LS, Matthews BW. Protein Sci 2 1274-1284 (1993)
  27. A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities. Barton JL, Herbst R, Bosisio D, Higgins L, Nicklin MJ. Eur J Immunol 30 3299-3308 (2000)
  28. SQUID: a program for the analysis and display of data from crystallography and molecular dynamics. Oldfield TJ. J Mol Graph 10 247-252 (1992)
  29. A procedure for the automatic determination of hydrophobic cores in protein structures. Swindells MB. Protein Sci 4 93-102 (1995)
  30. Formation of an active dimer during storage of interleukin-1 receptor antagonist in aqueous solution. Chang BS, Beauvais RM, Arakawa T, Narhi LO, Dong A, Aparisio DI, Carpenter JF. Biophys J 71 3399-3406 (1996)
  31. The native energy landscape for interleukin-1beta. Modulation of the population ensemble through native-state topology. Roy M, Chavez LL, Finke JM, Heidary DK, Onuchic JN, Jennings PA. J Mol Biol 348 335-347 (2005)
  32. Water in the polar and nonpolar cavities of the protein interleukin-1β. Yin H, Feng G, Clore GM, Hummer G, Rasaiah JC. J Phys Chem B 114 16290-16297 (2010)
  33. Why protein R-factors are so large: a self-consistent analysis. Vitkup D, Ringe D, Karplus M, Petsko GA. Proteins 46 345-354 (2002)
  34. Structural basis for sugar recognition, including the Tn carcinoma antigen, by the lectin SNA-II from Sambucus nigra. Maveyraud L, Niwa H, Guillet V, Svergun DI, Konarev PV, Palmer RA, Peumans WJ, Rougé P, Van Damme EJ, Reynolds CD, Mourey L. Proteins 75 89-103 (2009)
  35. The crystal structure of human glycosylation-inhibiting factor is a trimeric barrel with three 6-stranded beta-sheets. Kato Y, Muto T, Tomura T, Tsumura H, Watarai H, Mikayama T, Ishizaka K, Kuroki R. Proc Natl Acad Sci U S A 93 3007-3010 (1996)
  36. Insertion of a structural domain of interleukin (IL)-1 beta confers agonist activity to the IL-1 receptor antagonist. Implications for IL-1 bioactivity. Greenfeder SA, Varnell T, Powers G, Lombard-Gillooly K, Shuster D, McIntyre KW, Ryan DE, Levin W, Madison V, Ju G. J Biol Chem 270 22460-22466 (1995)
  37. Determination of solvent content in cavities in IL-1beta using experimentally phased electron density. Quillin ML, Wingfield PT, Matthews BW. Proc Natl Acad Sci U S A 103 19749-19753 (2006)
  38. Inclusion body formation by interleukin-1 beta depends on the thermal sensitivity of a folding intermediate. Wetzel R, Chrunyk BA. FEBS Lett 350 245-248 (1994)
  39. Real-time NMR kinetic studies provide global and residue-specific information on the non-cooperative unfolding of the beta-trefoil protein, interleukin-1beta. Roy M, Jennings PA. J Mol Biol 328 693-703 (2003)
  40. Comparison of the solution nuclear magnetic resonance and X-ray crystal structures of human recombinant interleukin-1 beta. Clore GM, Gronenborn AM. J Mol Biol 221 47-53 (1991)
  41. Correlation between the 1.6 A crystal structure and mutational analysis of keratinocyte growth factor. Osslund TD, Syed R, Singer E, Hsu EW, Nybo R, Chen BL, Harvey T, Arakawa T, Narhi LO, Chirino A, Morris CF. Protein Sci 7 1681-1690 (1998)
  42. Spontaneous drying of non-polar deep-cavity cavitand pockets in aqueous solution. Barnett JW, Sullivan MR, Long JA, Tang D, Nguyen T, Ben-Amotz D, Gibb BC, Ashbaugh HS. Nat Chem 12 589-594 (2020)
  43. Molecular modeling of the steric structure of the envelope F1 antigen of Yersinia pestis. Zav'yalov V, Denesyuk A, Zav'yalova G, Korpela T. Immunol Lett 45 19-22 (1995)
  44. β-Bulge triggers route-switching on the functional landscape of interleukin-1β. Capraro DT, Roy M, Onuchic JN, Gosavi S, Jennings PA. Proc Natl Acad Sci U S A 109 1490-1493 (2012)
  45. The liverwort contains a lectin that is structurally and evolutionary related to the monocot mannose-binding lectins. Peumans WJ, Barre A, Bras J, Rougé P, Proost P, Van Damme EJ. Plant Physiol 129 1054-1065 (2002)
  46. The structure of murine interleukin-1 beta at 2.8 A resolution. van Oostrum J, Priestle JP, Grütter MG, Schmitz A. J Struct Biol 107 189-195 (1991)
  47. Cloning, sequence analysis and crystal structure determination of a miraculin-like protein from Murraya koenigii. Gahloth D, Selvakumar P, Shee C, Kumar P, Sharma AK. Arch Biochem Biophys 494 15-22 (2010)
  48. Deletion mutants of human interleukin 1 beta with significantly reduced agonist properties: search for the agonist/antagonist switch in ligands to the interleukin 1 receptors. Simoncsits A, Bristulf J, Tjörnhammar ML, Cserzö M, Pongor S, Rybakina E, Gatti S, Bartfai T. Cytokine 6 206-214 (1994)
  49. Three topologically equivalent core residues affect the transition state ensemble in a protein folding reaction. Heidary DK, Jennings PA. J Mol Biol 316 789-798 (2002)
  50. Cytokine conformations: predictive studies. Parry DA, Minasian E, Leach SJ. J Mol Recognit 4 63-75 (1991)
  51. Long-range coupling between separate docking sites in interleukin-1beta. Heidary DK, Roy M, Daumy GO, Cong Y, Jennings PA. J Mol Biol 353 1187-1198 (2005)
  52. Refined crystal structure (2.3 A) of a double-headed winged bean alpha-chymotrypsin inhibitor and location of its second reactive site. Dattagupta JK, Podder A, Chakrabarti C, Sen U, Mukhopadhyay D, Dutta SK, Singh M. Proteins 35 321-331 (1999)
  53. Production and comprehensive quality control of recombinant human Interleukin-1beta: a case study for a process development strategy. Block H, Kubicek J, Labahn J, Roth U, Schäfer F. Protein Expr Purif 57 244-254 (2008)
  54. Mechanistic investigation into complementary (antisense) peptide mini-receptor inhibitors of cytokine interleukin-1. Hea JR, Bino S, Roberts GW, Raynes JG, Miller AD. Chembiochem 3 76-85 (2002)
  55. A bicistronic expression system for bacterial production of authentic human interleukin-18. Kirkpatrick RB, McDevitt PJ, Matico RE, Nwagwu S, Trulli SH, Mao J, Moore DD, Yorke AF, McLaughlin MM, Knecht KA, Elefante LC, Calamari AS, Fornwald JA, Trill JJ, Jonak ZL, Kane J, Patel PS, Sathe GM, Shatzman AR, Tapley PM, Johanson KO. Protein Expr Purif 27 279-292 (2003)
  56. Biophysical characterization of structural properties and folding of interleukin-1 receptor antagonist. Latypov RF, Harvey TS, Liu D, Bondarenko PV, Kohno T, Fachini RA, Rosenfeld RD, Ketchem RR, Brems DN, Raibekas AA. J Mol Biol 368 1187-1201 (2007)
  57. Initiating a crystallographic study of a class II fructose-1,6-bisphosphate aldolase. Naismith JH, Ferrara JD, Bailey S, Marshall K, Dauter Z, Wilson KS, Habash J, Harrop SJ, Berry AJ, Hunter WN. J Mol Biol 225 1137-1141 (1992)
  58. Solution structure of human interleukin-1 receptor antagonist protein. Stockman BJ, Scahill TA, Strakalaitis NA, Brunner DP, Yem AW, Deibel MR. FEBS Lett 349 79-83 (1994)
  59. Structure and function of interleukin-1, based on crystallographic and modeling studies. Veerapandian B. Biophys J 62 112-115 (1992)
  60. Proximal charge effects on guest binding to a non-polar pocket. Suating P, Nguyen TT, Ernst NE, Wang Y, Jordan JH, Gibb CLD, Ashbaugh HS, Gibb BC. Chem Sci 11 3656-3663 (2020)
  61. Arg-27, Arg-127 and Arg-155 in the beta-trefoil protein barley alpha-amylase/subtilisin inhibitor are interface residues in the complex with barley alpha-amylase 2. Rodenburg KW, Várallyay E, Svendsen I, Svensson B. Biochem J 309 ( Pt 3) 969-976 (1995)
  62. Bacterial production of biologically active canine interleukin-1beta by seamless SUMO tagging and removal. Kirkpatrick RB, Grooms M, Wang F, Fenderson H, Feild J, Pratta MA, Volker C, Scott G, Johanson K. Protein Expr Purif 50 102-110 (2006)
  63. Basic fibroblast growth factor is a beta-rich protein. Wu CS, Thompson SA, Yang JT. J Protein Chem 10 427-436 (1991)
  64. Low resolution structure of interleukin-1 beta in solution derived from 1H-15N heteronuclear three-dimensional nuclear magnetic resonance spectroscopy. Clore GM, Driscoll PC, Wingfield PT, Gronenborn AM. J Mol Biol 214 811-817 (1990)
  65. Structural and functional comparison of cytokine interleukin-1 beta from chicken and human. Cheng CS, Chen WT, Lee LH, Chen YW, Chang SY, Lyu PC, Yin HS. Mol Immunol 48 947-955 (2011)
  66. Sublytic gasdermin-D pores captured in atomistic molecular simulations. Schaefer SL, Hummer G. Elife 11 e81432 (2022)
  67. Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1β protein in dorsal hippocampus. Frank MG, Baratta MV, Zhang K, Fallon IP, Pearson MA, Liu G, Hutchinson MR, Watkins LR, Goldys EM, Maier SF. Brain Behav Immun 90 70-80 (2020)
  68. Molecular dynamics free energy calculations to assess the possibility of water existence in protein nonpolar cavities. Oikawa M, Yonetani Y. Biophys J 98 2974-2983 (2010)
  69. Crystallization studies of glycosylated and unglycosylated human recombinant interleukin-2. Stura EA, Chen P, Wilmot CM, Arevalo JH, Wilson IA. Proteins 12 24-30 (1992)
  70. Modeling the structure of Pyrococcus furiosus rubredoxin by homology to other X-ray structures. Wampler JE, Bradley EA, Stewart DE, Adams MW. Protein Sci 2 640-649 (1993)
  71. Sequence and structural relationships in the cytokine family. Manavalan P, Swope DL, Withy RM. J Protein Chem 11 321-331 (1992)
  72. Chemical modification of interleukin-1 beta: biochemical characterization of a carbodiimide-catalyzed intramolecular cross-linked protein. Yem AW, Guido DM, Mathews WR, Staite ND, Richard KA, Prairie MD, Krueger WC, Epps DE, Deibel MR. J Protein Chem 11 709-722 (1992)
  73. Comparative analysis of receptor binding by chicken and human interleukin-1β. Cheng CS, Lu WS, Tu IF, Lyu PC, Yin HS. J Mol Model 17 1283-1294 (2011)
  74. Altered backbone and side-chain interactions result in route heterogeneity during the folding of interleukin-1β (IL-1β). Capraro DT, Lammert H, Heidary DK, Roy M, Gross LA, Onuchic JN, Jennings PA. Biophys J 105 975-983 (2013)
  75. Crystals of soluble interleukin-1 receptor complexed with its natural antagonist reveal a 1:1 receptor-ligand complex. Schreuder H, Tardif C, Soffientini A, Sarubbi E, Akeson A, Bowlin T, Yanofsky S, Barrett RW. FEBS Lett 373 39-40 (1995)
  76. EXTRACT: a program to extract three-dimensional coordinates from stereo diagrams of proteins. Oldfield TJ, Hubbard RE. J Mol Graph 13 18-23, 52 (1995)
  77. Progesterone Reduces ATP-Induced Pyroptosis of SH-SY5Y Cells. Cui C, Wang X, Zhang S, Wu H, Li M, Dong L, Yan C, Li D. Biomed Res Int 2022 4827444 (2022)
  78. Solution structure and dynamics of a serpin reactive site loop using interleukin 1beta as a presentation scaffold. Arico-Muendel CC, Patera A, Pochapsky TC, Kuti M, Wolfson AJ. Protein Eng 12 189-202 (1999)
  79. Synthetic alleles at position 121 define a functional domain of human interleukin-1 beta. Ambrosetti DC, Palla E, Mirtella A, Galeotti C, Solito E, Navarra P, Parente L, Melli M. Eur J Biochem 238 308-316 (1996)
  80. Interleukin-1 beta-specific partial agonists defined by site-directed mutagenesis studies. Guinet F, Guitton JD, Gault N, Folliard F, Touchet N, Cherel JM, Crespo A, Destourbe A, Bertrand P, Denefle P. Eur J Biochem 211 583-590 (1993)
  81. Reconstruction of the 3D coordinates of alpha-carbon atoms of proteins from a pair of stereographic figures. Iwata Y, Kasuya A, Miyamoto S. J Comput Aided Mol Des 10 558-566 (1996)
  82. On the Nature of Guest Complexation in Water: Triggered Wetting-Water-Mediated Binding. Suating P, Ernst NE, Alagbe BD, Skinner HA, Mague JT, Ashbaugh HS, Gibb BC. J Phys Chem B 126 3150-3160 (2022)
  83. Prediction of hydrophilic and hydrophobic hydration structure of protein by neural network optimized using experimental data. Sato K, Oide M, Nakasako M. Sci Rep 13 2183 (2023)


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