PDBe 1i09

X-ray diffraction
2.7Å resolution

STRUCTURE OF GLYCOGEN SYNTHASE KINASE-3 (GSK3B)

Released:
Source organism: Homo sapiens
Primary publication:
Structure of GSK3beta reveals a primed phosphorylation mechanism.
Nat. Struct. Biol. 8 593-6 (2001)
PMID: 11427888

Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein. 
ATP + [tau protein] = ADP + [tau protein] phosphate. 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 420 amino acids
Theoretical weight: 46.8 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P49841 (Residues: 1-420; Coverage: 100%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 83.272Å b: 86.725Å c: 177.917Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.242 0.274
Expression system: unidentified baculovirus