PDBe 1hzh

X-ray diffraction
2.7Å resolution

CRYSTAL STRUCTURE OF THE INTACT HUMAN IGG B12 WITH BROAD AND POTENT ACTIVITY AGAINST PRIMARY HIV-1 ISOLATES: A TEMPLATE FOR HIV VACCINE DESIGN

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Immunoglobulin heavy constant gamma 1 Chains: H, K
Molecule details ›
Chains: H, K
Length: 457 amino acids
Theoretical weight: 50.47 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Best match: P01857 (Residues: 1-330)
Gene name: IGHG1
Immunoglobulin kappa constant Chains: L, M
Molecule details ›
Chains: L, M
Length: 215 amino acids
Theoretical weight: 23.71 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Best match: P01834 (Residues: 1-107)
Gene name: IGKC

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: R32
Unit cell:
a: 271.32Å b: 271.32Å c: 175.18Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.229 0.229 0.273
Expression system: Cricetulus griseus