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C4ADG FRAGMENT OF HUMAN COMPLEMENT FACTOR C4A

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: extracellular space

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EC 3.4.21.43: Classical-complement-pathway C3/C5 convertase

Reaction catalysed:
Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|- bond in complement component C5 alpha-chain to form C5a and C5b.
Alternative Name(s):
  • C3 convertase
  • C42
  • C42
  • C423
  • C423
  • C4b,2a
  • C4b,2a,3b
  • C5 convertase
  • Complement C2
  • Complement C3 convertase
  • Complement C42

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF07678
Domain description: A-macroglobulin TED domain
Occurring in:
  1. C4d-A
The deposited structure of PDB entry 1hzf contains 1 copy of Pfam domain PF07678 (A-macroglobulin TED domain) in C4d-A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR019742
Domain description: Alpha-2-macroglobulin, conserved site
Occurring in:
  1. C4d-A
IPR047565
Domain description: Alpha-macroglobulin-like, thiol-ester bond-forming region
Occurring in:
  1. C4d-A
IPR008930
Domain description: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Occurring in:
  1. C4d-A
IPR011626
Domain description: Alpha-macroglobulin-like, TED domain
Occurring in:
  1. C4d-A

Structure domain

CATH CATH domain
1.50.10.20
Class: Mainly Alpha
Architecture: Alpha/alpha barrel
Topology: Glycosyltransferase
Homology: Glycosyltransferase
Occurring in:
  1. C4d-A
The deposited structure of PDB entry 1hzf contains 1 copy of CATH domain 1.50.10.20 (Glycosyltransferase) in C4d-A. Showing 1 copy in chain A.
SCOP SCOP annotation
48251
Class: All alpha proteins
Fold: alpha/alpha toroid
Superfamily: Terpenoid cyclases/Protein prenyltransferases
Occurring in:
  1. C4d-A
The deposited structure of PDB entry 1hzf contains 1 copy of SCOP domain 48251 (Complement components) in C4d-A. Showing 1 copy in chain A.

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