PDBe 1hxy

X-ray diffraction
2.6Å resolution

CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H IN COMPLEX WITH HUMAN MHC CLASS II

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Enterotoxin type H Chain: D
Molecule details ›
Chain: D
Length: 213 amino acids
Theoretical weight: 24.69 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A0M0 (Residues: 25-237; Coverage: 98%)
Gene names: entH, seh
Sequence domains:
Structure domains:
Hemagglutinin HA1 chain Chain: C
Molecule details ›
Chain: C
Length: 13 amino acids
Theoretical weight: 1.51 KDa
Source organism: Influenza A virus (A/equine/Jilin/1/1989(H3N8))
Expression system: Not provided
UniProt:
  • Canonical: Q03909 (Residues: 327-339; Coverage: 2%)
Gene name: HA
HLA class II histocompatibility antigen, DR alpha chain Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 21.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01903 (Residues: 26-207; Coverage: 80%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DRB1-1 beta chain Chain: B
Molecule details ›
Chain: B
Length: 190 amino acids
Theoretical weight: 22.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04229 (Residues: 30-219; Coverage: 80%)
Gene name: HLA-DRB1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: C2
Unit cell:
a: 123.624Å b: 122.843Å c: 48.513Å
α: 90° β: 100.13° γ: 90°
R-values:
R R work R free
0.202 0.202 0.258
Expression systems:
  • Escherichia coli
  • Not provided