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INSULIN MUTANT (B1, B10, B16, B27)GLU, DES-B30, NMR, 25 STRUCTURES

Solution NMR
PDB entry 1hui coloured by chain, ensemble of 25 models, front view.
PDB entry 1hui coloured by chain, ensemble of 25 models, side view.
PDB entry 1hui coloured by chain, ensemble of 25 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Insulin complex
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Multimeric state: hetero dimer
Accessible surface area: 4026.99 Å2
Buried surface area: 1229.63 Å2
Dissociation area: 614.81 Å2
Dissociation energy (ΔGdiss): 10.46 kcal/mol
Dissociation entropy (TΔSdiss): 8.14 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134182
Complex Portal ID: CPX-943

Macromolecules

Insulin A chain
Chain: A
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
InterPro:
SCOP: Insulin-like
Insulin A chain in PDB entry 1hui, assembly 1, front view.
Insulin A chain in PDB entry 1hui, assembly 1, side view.
Insulin A chain in PDB entry 1hui, assembly 1, top view.
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Insulin B chain
Chain: B
Length: 29 amino acids
Theoretical weight: 3.3 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P01308 (Residues: 26-53; Coverage: 33%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
SCOP: Insulin-like
Insulin B chain in PDB entry 1hui, assembly 1, front view.
Insulin B chain in PDB entry 1hui, assembly 1, side view.
Insulin B chain in PDB entry 1hui, assembly 1, top view.
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