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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN TRIOSEPHOSPHATE ISOMERASE AT 2.8 ANGSTROMS RESOLUTION. TRIOSEPHOSPHATE ISOMERASE RELATED HUMAN GENETIC DISORDERS AND COMPARISON WITH THE TRYPANOSOMAL ENZYME

Source organism: Homo sapiens
Biochemical function: protein homodimerization activity
Biological process: canonical glycolysis
Cellular component: extracellular exosome

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EC 5.3.1.1: Triose-phosphate isomerase

Reaction catalysed:
D-glyceraldehyde 3-phosphate = glycerone phosphate
Systematic name:
D-glyceraldehyde-3-phosphate aldose-ketose-isomerase
Alternative Name(s):
  • D-glyceraldehyde-3-phosphate ketol-isomerase
  • Phosphotriose isomerase
  • Triose phosphate mutase
  • Triose phosphoisomerase
  • Triosephosphate isomerase
  • Triosephosphate mutase

EC 4.2.3.3: Methylglyoxal synthase

Reaction catalysed:
Glycerone phosphate = methylglyoxal + phosphate
Systematic name:
Glycerone-phosphate phosphate-lyase (methylglyoxal-forming)
Alternative Name(s):
  • Glycerone-phosphate phospho-lyase
  • Methylglyoxal synthetase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00121
Domain description: Triosephosphate isomerase
Occurring in:
  1. Triosephosphate isomerase
The deposited structure of PDB entry 1hti contains 2 copies of Pfam domain PF00121 (Triosephosphate isomerase) in Triosephosphate isomerase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000652
Domain description: Triosephosphate isomerase
Occurring in:
  1. Triosephosphate isomerase
IPR020861
Domain description: Triosephosphate isomerase, active site
Occurring in:
  1. Triosephosphate isomerase
IPR022896
Domain description: Triosephosphate isomerase, bacterial/eukaryotic
Occurring in:
  1. Triosephosphate isomerase
IPR035990
Domain description: Triosephosphate isomerase superfamily
Occurring in:
  1. Triosephosphate isomerase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Triosephosphate isomerase

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Triosephosphate isomerase
The deposited structure of PDB entry 1hti contains 2 copies of CATH domain 3.20.20.70 (TIM Barrel) in Triosephosphate isomerase. Showing 1 copy in chain A.
SCOP SCOP annotation
51352
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Triosephosphate isomerase (TIM)
Occurring in:
  1. Triosephosphate isomerase
The deposited structure of PDB entry 1hti contains 2 copies of SCOP domain 51352 (Triosephosphate isomerase (TIM)) in Triosephosphate isomerase. Showing 1 copy in chain A.

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