PDBe 1ht8

X-ray diffraction
2.69Å resolution

THE 2.7 ANGSTROM RESOLUTION MODEL OF OVINE COX-1 COMPLEXED WITH ALCLOFENAC

Released:

Function and Biology Details

Reaction catalysed:
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin G/H synthase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 551 amino acids
Theoretical weight: 63.51 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: P05979 (Residues: 33-583; Coverage: 96%)
Gene names: COX1, PTGS1
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: I222
Unit cell:
a: 99.149Å b: 208.45Å c: 222.399Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.211 0.242