Function and Biology

SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

EC 3.1.4.11: Phosphoinositide phospholipase C

Reaction catalysed:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Comments:
  • These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3).
  • They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.
Systematic name:
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
Alternative Name(s):
  • 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
  • Monophosphatidylinositol phosphodiesterase
  • Phosphatidylinositol phospholipase C
  • Phosphoinositidase C
  • Triphosphoinositide phosphodiesterase
  • PI-PLC

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00018
Domain description: SH3 domain
Occurring in:
  1. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
1 copy of Pfam domain PF00018 (SH3 domain) in 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 in PDB 1hsq.

InterPro InterPro annotations
IPR001452
Domain description: SH3 domain
Occurring in:
  1. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
IPR035724
Domain description: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain
Occurring in:
  1. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
IPR036028
Domain description: SH3-like domain superfamily
Occurring in:
  1. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Structure domain

CATH CATH domain
2.30.30.40
Class: Mainly Beta
Architecture: Roll
Topology: SH3 type barrels.
Homology: SH3 Domains
Occurring in:
  1. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
1 copy of CATH domain 2.30.30.40 (SH3 type barrels.) in 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 in PDB 1hsq.
SCOP SCOP annotation
50045
Class: All beta proteins
Fold: SH3-like barrel
Superfamily: SH3-domain
Occurring in:
  1. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
1 copy of SCOP domain 50045 (SH3-domain) in 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 in PDB 1hsq.