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THE ANTIGENIC IDENTITY OF PEPTIDE(SLASH)MHC COMPLEXES: A COMPARISON OF THE CONFORMATION OF FIVE PEPTIDES PRESENTED BY HLA-A2

X-ray diffraction
2.5Å resolution
PDB entry 1hhk coloured by chain, front view.
PDB entry 1hhk coloured by chain, side view.
PDB entry 1hhk coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 19049.19 Å2
Buried surface area: 4382.94 Å2
Dissociation area: 1,323.73 Å2
Dissociation energy (ΔGdiss): 7.79 kcal/mol
Dissociation entropy (TΔSdiss): 12.1 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137667
Assembly 2
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Multimeric state: hetero trimer
Accessible surface area: 18952.04 Å2
Buried surface area: 4433.07 Å2
Dissociation area: 1,353.79 Å2
Dissociation energy (ΔGdiss): 8.1 kcal/mol
Dissociation entropy (TΔSdiss): 12.11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137667

Macromolecules

HLA class I histocompatibility antigen, A alpha chain
Chains: A, D
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Pfam:
InterPro:
CATH:
SCOP:
HLA class I histocompatibility antigen, A alpha chain in PDB entry 1hhk, assembly 1, front view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 1hhk, assembly 1, side view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 1hhk, assembly 1, top view.
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Beta-2-microglobulin
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
SCOP: C1 set domains (antibody constant domain-like)
Beta-2-microglobulin in PDB entry 1hhk, assembly 1, front view.
Beta-2-microglobulin in PDB entry 1hhk, assembly 1, side view.
Beta-2-microglobulin in PDB entry 1hhk, assembly 1, top view.
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Protein Tax-1
Chains: C, F
Length: 9 amino acids
Theoretical weight: 1.07 KDa
Source organism: Human T-cell leukemia virus type I
Expression system: Not provided
UniProt:
  • Canonical: P14079 (Residues: 11-19; Coverage: 3%)
Gene name: tax
Protein Tax-1 in PDB entry 1hhk, assembly 1, front view.
Protein Tax-1 in PDB entry 1hhk, assembly 1, side view.
Protein Tax-1 in PDB entry 1hhk, assembly 1, top view.
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