PDBe 1hh8

X-ray diffraction
1.8Å resolution

The active N-terminal region of p67phox: Structure at 1.8 Angstrom resolution and biochemical characterizations of the A128V mutant implicated in chronic granulomatous disease

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutrophil cytosol factor 2 Chain: A
Molecule details ›
Chain: A
Length: 213 amino acids
Theoretical weight: 24.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19878 (Residues: 1-213; Coverage: 41%)
Gene names: NCF2, NOXA2, P67PHOX
Sequence domains: Tetratricopeptide repeat
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P31
Unit cell:
a: 67.67Å b: 67.67Å c: 50.2Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.182 0.182 0.204
Expression system: Escherichia coli BL21(DE3)