› › Structure analysis

Rac1-RhoGDI complex involved in NADPH oxidase activation

X-ray diffraction
2.7Å resolution
PDB entry 1hh4 coloured by chain, front view.
PDB entry 1hh4 coloured by chain, side view.
PDB entry 1hh4 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Ras-related C3 botulinum toxin substrate 1 and Rho GDP-dissociation inhibitor 1
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 19300.81 Å2
Buried surface area: 4924.5 Å2
Dissociation area: 1,951.01 Å2
Dissociation energy (ΔGdiss): 9.31 kcal/mol
Dissociation entropy (TΔSdiss): 12.53 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156567
Assembly 2
Download    3D Visualisation
Assembly Name: Ras-related C3 botulinum toxin substrate 1 and Rho GDP-dissociation inhibitor 1
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 18760.64 Å2
Buried surface area: 4673.69 Å2
Dissociation area: 1,844.17 Å2
Dissociation energy (ΔGdiss): 8.92 kcal/mol
Dissociation entropy (TΔSdiss): 12.49 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156567

Macromolecules

Ras-related C3 botulinum toxin substrate 1
Chains: A, B
Length: 192 amino acids
Theoretical weight: 21.38 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63000 (Residues: 2-192; Coverage: 100%)
Gene names: MIG5, RAC1, TC25
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
SCOP: G proteins
Ras-related C3 botulinum toxin substrate 1 in PDB entry 1hh4, assembly 1, front view.
Ras-related C3 botulinum toxin substrate 1 in PDB entry 1hh4, assembly 1, side view.
Ras-related C3 botulinum toxin substrate 1 in PDB entry 1hh4, assembly 1, top view.
Molecule details ›

Search similar proteins

Rho GDP-dissociation inhibitor 1
Chains: D, E
Length: 204 amino acids
Theoretical weight: 23.24 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P52565 (Residues: 1-204; Coverage: 100%)
Gene names: ARHGDIA, GDIA1
Pfam: RHO protein GDP dissociation inhibitor
InterPro:
CATH: Coagulation Factor XIII, subunit A, domain 1
SCOP: RhoGDI-like
Rho GDP-dissociation inhibitor 1 in PDB entry 1hh4, assembly 1, front view.
Rho GDP-dissociation inhibitor 1 in PDB entry 1hh4, assembly 1, side view.
Rho GDP-dissociation inhibitor 1 in PDB entry 1hh4, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links