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THE CRYSTALLOGRAPHIC STRUCTURE OF A HUMAN DIHYDROPTERIDINE REDUCTASE NADH BINARY COMPLEX EXPRESSED IN ESCHERICHIA COLI BY A CDNA CONSTRUCTED FROM ITS RAT HOMOLOGUE

X-ray diffraction
2.5Å resolution
PDB entry 1hdr coloured by chain, front view.
PDB entry 1hdr coloured by chain, side view.
PDB entry 1hdr coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Dihydropteridine reductase
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Multimeric state: homo dimer
Accessible surface area: 18689.92 Å2
Buried surface area: 5916.54 Å2
Dissociation area: 1,807.59 Å2
Dissociation energy (ΔGdiss): 26.84 kcal/mol
Dissociation entropy (TΔSdiss): 13.11 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-140649

Macromolecules

Dihydropteridine reductase
Chain: A
Length: 244 amino acids
Theoretical weight: 25.82 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P09417 (Residues: 1-244; Coverage: 100%)
Gene names: DHPR, QDPR, SDR33C1
Pfam: short chain dehydrogenase
InterPro:
CATH: NAD(P)-binding Rossmann-like Domain
SCOP: Tyrosine-dependent oxidoreductases
Dihydropteridine reductase in PDB entry 1hdr, assembly 1, front view.
Dihydropteridine reductase in PDB entry 1hdr, assembly 1, side view.
Dihydropteridine reductase in PDB entry 1hdr, assembly 1, top view.
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