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CRYSTAL STRUCTURE OF AN ENGRAILED HOMEODOMAIN-DNA COMPLEX AT 2.8 ANGSTROMS RESOLUTION: A FRAMEWORK FOR UNDERSTANDING HOMEODOMAIN-DNA INTERACTIONS

X-ray diffraction
2.8Å resolution
PDB entry 1hdd coloured by chain, front view.
PDB entry 1hdd coloured by chain, side view.
PDB entry 1hdd coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Segmentation polarity homeobox protein engrailed and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 13842.44 Å2
Buried surface area: 4680.1 Å2
Dissociation area: 477.82 Å2
Dissociation energy (ΔGdiss): 1.36 kcal/mol
Dissociation entropy (TΔSdiss): 10.39 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-113895

Macromolecules

Segmentation polarity homeobox protein engrailed
Chains: C, D
Length: 61 amino acids
Theoretical weight: 7.47 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: P02836 (Residues: 453-512; Coverage: 11%)
Gene names: CG9015, en
Pfam: Homeodomain
InterPro:
CATH: Homeodomain-like
SCOP: Homeodomain
Segmentation polarity homeobox protein engrailed in PDB entry 1hdd, assembly 1, front view.
Segmentation polarity homeobox protein engrailed in PDB entry 1hdd, assembly 1, side view.
Segmentation polarity homeobox protein engrailed in PDB entry 1hdd, assembly 1, top view.
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DNA chain A
Name: DNA (5'-D(*TP*TP*TP*TP*GP*CP*CP*AP*TP*GP*TP*AP*AP*TP*TP*AP*C P*CP*TP*AP*A)-3')
Representative chains: A
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 21 nucleotides
Theoretical weight: 6.39 KDa
DNA (5'-D(*TP*TP*TP*TP*GP*CP*CP*AP*TP*GP*TP*AP*AP*TP*TP*AP*C P*CP*TP*AP*A)-3') in PDB entry 1hdd, assembly 1, front view.
DNA (5'-D(*TP*TP*TP*TP*GP*CP*CP*AP*TP*GP*TP*AP*AP*TP*TP*AP*C P*CP*TP*AP*A)-3') in PDB entry 1hdd, assembly 1, side view.
DNA (5'-D(*TP*TP*TP*TP*GP*CP*CP*AP*TP*GP*TP*AP*AP*TP*TP*AP*C P*CP*TP*AP*A)-3') in PDB entry 1hdd, assembly 1, top view.
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DNA chain B
Name: DNA (5'-D(*AP*TP*TP*AP*GP*GP*TP*AP*AP*TP*TP*AP*CP*AP*TP*GP*G P*CP*AP*AP*A)-3')
Representative chains: B
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 21 nucleotides
Theoretical weight: 6.49 KDa
DNA (5'-D(*AP*TP*TP*AP*GP*GP*TP*AP*AP*TP*TP*AP*CP*AP*TP*GP*G P*CP*AP*AP*A)-3') in PDB entry 1hdd, assembly 1, front view.
DNA (5'-D(*AP*TP*TP*AP*GP*GP*TP*AP*AP*TP*TP*AP*CP*AP*TP*GP*G P*CP*AP*AP*A)-3') in PDB entry 1hdd, assembly 1, side view.
DNA (5'-D(*AP*TP*TP*AP*GP*GP*TP*AP*AP*TP*TP*AP*CP*AP*TP*GP*G P*CP*AP*AP*A)-3') in PDB entry 1hdd, assembly 1, top view.
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