› 1hcs

Solution NMR

NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX

Released:
DOI: 10.2210/pdb1hcs/pdb
PDB entry 1hcs coloured by chain, front view.
PDB entry 1hcs coloured by chain, side view.
PDB entry 1hcs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide.
Xu RX, Word JM, Davis DG, Rink MJ, Willard DH, Gampe RT
Biochemistry 34 2107-21 (1995)
PMID: 7532003

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146383 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ACETYL-PYEEIE-OH Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 788 Da
Source organism: Homo sapiens
Expression system: Not provided
Proto-oncogene tyrosine-protein kinase Src Chain: B
Molecule details ›
Chain: B
Length: 107 amino acids
Theoretical weight: 12.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P12931 (Residues: 144-249; Coverage: 20%)
Gene names: SRC, SRC1
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
Expression systems:
  • Not provided
  • Escherichia coli BL21

Quick links

Citations

6 review citations

Modular peptide recognition domains in eukaryotic signaling.
Kuriyan et al. (1997)
5 more

1 mention without citation

Network pharmacology and molecular docking reveal potential mechanism of esculetin in the treatment of ulcerative colitis.
Cai et al. (2023)