Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
Structure domains:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Coagulation factor Xa complex (preferred)
PDBe Complex ID:
PDB-CPX-133209 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Activated factor Xa heavy chain
Molecule details ›
Chain: A
Length: 241 amino acids
Theoretical weight: 27.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 241 amino acids
Theoretical weight: 27.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical:
P00742 (Residues: 235-475; Coverage: 53%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Factor X light chain
Molecule details ›
Chain: B
Length: 51 amino acids
Theoretical weight: 5.5 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Coagulation Factor Xa inhibitory site
Structure domains: Laminin
Length: 51 amino acids
Theoretical weight: 5.5 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P00742 (Residues: 129-179; Coverage: 11%)
Sequence domains: Coagulation Factor Xa inhibitory site
Structure domains: Laminin
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Spacegroup:
P41212
Expression system: Not provided
