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COMPLEX OF HUMAN ALPHA-THROMBIN WITH A 15MER OLIGONUCLEOTIDE GGTTGGTGTGGTTGG (BASED ON NMR MODEL OF DNA)

X-ray diffraction
2.8Å resolution
PDB entry 1hao coloured by chain, front view.
PDB entry 1hao coloured by chain, side view.
PDB entry 1hao coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: alpha-thrombin complex and DNA
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Multimeric state: hetero trimer
Accessible surface area: 14248.17 Å2
Buried surface area: 3219.24 Å2
Dissociation area: 546.58 Å2
Dissociation energy (ΔGdiss): -3.02 kcal/mol
Dissociation entropy (TΔSdiss): 9.96 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-113890

Macromolecules

Thrombin light chain
Chain: L
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2
Pfam: Thrombin light chain
InterPro:
SCOP: Eukaryotic proteases
Thrombin light chain in PDB entry 1hao, assembly 1, front view.
Thrombin light chain in PDB entry 1hao, assembly 1, side view.
Thrombin light chain in PDB entry 1hao, assembly 1, top view.
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Thrombin heavy chain
Chain: H
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Thrombin heavy chain in PDB entry 1hao, assembly 1, front view.
Thrombin heavy chain in PDB entry 1hao, assembly 1, side view.
Thrombin heavy chain in PDB entry 1hao, assembly 1, top view.
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DNA chain D
Name: DNA 5'-D(*GP*GP*TP*TP*GP*GP*TP*GP*TP*GP*GP*TP*TP*GP*G)-3'
Representative chains: D
Length: 15 nucleotides
Theoretical weight: 4.74 KDa
DNA 5'-D(*GP*GP*TP*TP*GP*GP*TP*GP*TP*GP*GP*TP*TP*GP*G)-3' in PDB entry 1hao, assembly 1, front view.
DNA 5'-D(*GP*GP*TP*TP*GP*GP*TP*GP*TP*GP*GP*TP*TP*GP*G)-3' in PDB entry 1hao, assembly 1, side view.
DNA 5'-D(*GP*GP*TP*TP*GP*GP*TP*GP*TP*GP*GP*TP*TP*GP*G)-3' in PDB entry 1hao, assembly 1, top view.
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