› 1ha4

X-ray diffraction
2.4Å resolution

GammaS crystallin C terminal domain from Homo Sapiens

Released:
DOI: 10.2210/pdb1ha4/pdb
PDB entry 1ha4 coloured by chain, front view.
PDB entry 1ha4 coloured by chain, side view.
PDB entry 1ha4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The X-ray crystal structure of human gamma S-crystallin C-terminal domain.
Purkiss AG, Bateman OA, Goodfellow JM, Lubsen NH, Slingsby C
J Biol Chem 277 4199-205 (2002)
PMID: 11706012

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149841 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gamma-crystallin S Chains: A, B
Molecule details ›
Chains: A, B
Length: 87 amino acids
Theoretical weight: 10.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P22914 (Residues: 92-178; Coverage: 49%)
Gene names: CRYG8, CRYGS
Sequence domains: Beta/Gamma crystallin
Structure domains: Crystallins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P6522
Unit cell:
a: 61.367Å b: 61.367Å c: 241.665Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.216 0.264
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Ageing and vision: structure, stability and function of lens crystallins.
Bloemendal et al. (2004)
1 more

9 mentions without citation

Evolution of crystallins for a role in the vertebrate eye lens.
Slingsby et al. (2013)
8 more