PDBe 1h7x

X-ray diffraction
2.01Å resolution

Dihydropyrimidine dehydrogenase (DPD) from pig, ternary complex of a mutant enzyme (C671A), NADPH and 5-fluorouracil


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Dihydropyrimidine dehydrogenase [NADP(+)] Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1025 amino acids
Theoretical weight: 111.57 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
  • Canonical: Q28943 (Residues: 1-1025; Coverage: 100%)
Gene name: DPYD
Sequence domains:
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: P21
Unit cell:
a: 81.95Å b: 159.29Å c: 163.57Å
α: 90° β: 96.04° γ: 90°
R R work R free
0.171 0.171 0.192
Expression system: Escherichia coli