PDBe 1h4l

X-ray diffraction
2.65Å resolution

Structure and regulation of the CDK5-p25(nck5a) complex

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclin-dependent-like kinase 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 292 amino acids
Theoretical weight: 33.36 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q00535 (Residues: 1-292; Coverage: 100%)
Gene names: CDK5, CDKN5
Sequence domains: Protein kinase domain
Structure domains:
Cyclin-dependent kinase 5 activator 1, p25 Chains: D, E
Molecule details ›
Chains: D, E
Length: 147 amino acids
Theoretical weight: 17.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q15078 (Residues: 147-293; Coverage: 48%)
Gene names: CDK5R, CDK5R1, NCK5A
Structure domains: Cyclin A; domain 1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7A
Spacegroup: C2
Unit cell:
a: 149.09Å b: 89.76Å c: 82.57Å
α: 90° β: 93.08° γ: 90°
R-values:
R R work R free
0.236 0.236 0.287
Expression system: Spodoptera frugiperda