PDBe 1h3b

X-ray diffraction
2.8Å resolution

SQUALENE-HOPENE CYCLASE

Released:

Function and Biology Details

Reactions catalysed:
Squalene = hop-22(29)-ene. 
Hopan-22-ol = squalene + H(2)O. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Squalene--hopene cyclase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 631 amino acids
Theoretical weight: 71.65 KDa
Source organism: Alicyclobacillus acidocaldarius
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P33247 (Residues: 1-631; Coverage: 100%)
Gene names: Aaci_2443, shc
Sequence domains:
Structure domains: Glycosyltransferase

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200B
Spacegroup: P3221
Unit cell:
a: 140.663Å b: 140.663Å c: 243.121Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.206 0.25
Expression system: Escherichia coli K-12