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Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide

X-ray diffraction
2.15Å resolution
PDB entry 1h2k coloured by chain, front view.
PDB entry 1h2k coloured by chain, side view.
PDB entry 1h2k coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hypoxia-inducible factor 1-alpha inhibitor and Hypoxia-inducible factor 1-alpha
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Multimeric state: hetero tetramer
Accessible surface area: 30294.2 Å2
Buried surface area: 10653.5 Å2
Dissociation area: 1,754.46 Å2
Dissociation energy (ΔGdiss): 26.84 kcal/mol
Dissociation entropy (TΔSdiss): 13.89 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-172550

Macromolecules

Hypoxia-inducible factor 1-alpha inhibitor
Chain: A
Length: 349 amino acids
Theoretical weight: 40.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NWT6 (Residues: 1-349; Coverage: 100%)
Gene names: FIH1, HIF1AN
Pfam: Cupin-like domain
InterPro:
CATH:
SCOP: Hypoxia-inducible factor HIF ihhibitor (FIH1)
Hypoxia-inducible factor 1-alpha inhibitor in PDB entry 1h2k, assembly 1, front view.
Hypoxia-inducible factor 1-alpha inhibitor in PDB entry 1h2k, assembly 1, side view.
Hypoxia-inducible factor 1-alpha inhibitor in PDB entry 1h2k, assembly 1, top view.
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Hypoxia-inducible factor 1-alpha
Chain: S
Length: 41 amino acids
Theoretical weight: 4.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16665 (Residues: 786-826; Coverage: 5%)
Gene names: BHLHE78, HIF1A, MOP1, PASD8
Pfam: HIF-1 alpha C terminal transactivation domain
InterPro: HIF-1 alpha, C-terminal transactivation domain
SCOP: Transactivation domain
Hypoxia-inducible factor 1-alpha in PDB entry 1h2k, assembly 1, front view.
Hypoxia-inducible factor 1-alpha in PDB entry 1h2k, assembly 1, side view.
Hypoxia-inducible factor 1-alpha in PDB entry 1h2k, assembly 1, top view.
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