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Crystal structure of human neutrophil elastase complexed with an inhibitor (GW475151)

X-ray diffraction
2Å resolution
PDB entry 1h1b coloured by chain, front view.
PDB entry 1h1b coloured by chain, side view.
PDB entry 1h1b coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Neutrophil elastase
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Multimeric state: homo dimer
Accessible surface area: 18163.63 Å2
Buried surface area: 5444.11 Å2
Dissociation area: 890.91 Å2
Dissociation energy (ΔGdiss): -4.99 kcal/mol
Dissociation entropy (TΔSdiss): 12.63 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-140069

Macromolecules

Neutrophil elastase
Chains: A, B
Length: 218 amino acids
Theoretical weight: 23.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08246 (Residues: 30-247; Coverage: 91%)
Gene names: ELA2, ELANE
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Neutrophil elastase in PDB entry 1h1b, assembly 1, front view.
Neutrophil elastase in PDB entry 1h1b, assembly 1, side view.
Neutrophil elastase in PDB entry 1h1b, assembly 1, top view.
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