PDBe 1gzk

X-ray diffraction
2.3Å resolution

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RAC-beta serine/threonine-protein kinase Chain: A
Molecule details ›
Chain: A
Length: 315 amino acids
Theoretical weight: 36.49 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P31751 (Residues: 146-460; Coverage: 66%)
Gene name: AKT2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P41212
Unit cell:
a: 148.405Å b: 148.405Å c: 38.547Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.248 0.248 0.319
Expression system: Spodoptera frugiperda