› 1gsy

X-ray diffraction
2.44Å resolution

GLUTATHIONE S-TRANSFERASE YFYF, CLASS PI, COMPLEXED WITH GLUTATHIONE

Released:
DOI: 10.2210/pdb1gsy/pdb
PDB entry 1gsy coloured by chain, front view.
PDB entry 1gsy coloured by chain, side view.
PDB entry 1gsy coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The three-dimensional structure of a class-Pi glutathione S-transferase complexed with glutathione: the active-site hydration provides insights into the reaction mechanism.
Párraga A, García-Sáez I, Walsh SB, Mantle TJ, Coll M
Biochem J 333 ( Pt 3) 811-6 (1998)
PMID: 9677344

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-148514 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase P 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 209 amino acids
Theoretical weight: 23.5 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P19157 (Residues: 2-210; Coverage: 100%)
Gene names: Gstp1, Gstpib
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GSH 2 x GSH
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-21
Spacegroup: C2221
Unit cell:
a: 142.68Å b: 162.57Å c: 63.32Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.194 not available

Quick links

Citations

11 citation in other articles

Proton release on binding of glutathione to alpha, Mu and Delta class glutathione transferases.
Caccuri et al. (1999)
10 more

1 mention without citation

Binding Direction-Based Two-Dimensional Flattened Contact Area Computing Algorithm for Protein-Protein Interactions.
Kang et al. (2017)